Fig. 1

Tumor size: MK delayed the tumor formation in BALB/c mice inoculated s.c. with 4T1 cells in fat pads. The differences between groups were determined by one-way ANOVA (∗for low risk groups while #for high risk groups; p < 0.05). Normal: normal healthy mice; LR untreated: untreated low risk mice inoculated with 1 × 10⁴ 4T1 cell/mice; LR MK 50 mg/kg: low risk mice treated with 50 mg/kg of MK extract for 30 days before inoculated with 1 × 10⁴4T1 cell/mice; LR MK 200 mg/kg: low risk mice treated with 200 mg/kg of MK extract for 30 days before inoculated with 1 × 10⁴4T1 cell/mice; HR untreated: untreated high risk mice inoculated with 1 × 10⁶4T1 cell/mice; HR MK 50 mg/kg: high risk mice treated with 50 mg/kg of MK extract for 30 days before inoculated with 1 × 10⁶4T1 cell/mice; HR MK 200 mg/kg: high risk mice treated with 200 mg/kg of MK extract for 30 days before inoculated with 1 × 10⁶4T1 cell/mice inoculated mice. LR: Low risk groups. HR: High risk groups