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Table 1 Effect of methanol extract on gastric secretion volume, pH, acid-output and ulcer index against indomethacin-pylorus ligation induced ulcer in rats

From: Gastroprotective mechanism of Paederia foetida Linn. (Rubiaceae) – a popular edible plant used by the tribal community of North-East India

Treatment Gastric secretion (Mean ± SEM) Ulcer index (mm) Mean ± SEM % of ulcer protection
Volume (ml) pH Acid output (Eq/100 g/4 h)
Group 1 (5 ml distilled water/kg) 2.114±0.13 2.80±0.01 2.80±0.01 2.850±0.07 -
Group 2 Indomethacin (25 mg/kg) 9.280±0.09ααα 1.07±0.01ααα 24.47±2.28ααα 39.12±0.81ααα -
Group3 MeOH PF (100 mg/kg) 4.296±0.11*** 2.51±0.02*** 10.99±0.11*** 10.57±0.15*** 72.98
Group 4 MeOH PF (200 mg/kg) 2.670±0.21*** 2.71±0.71*** 7.62±0.14*** 8.38±0.05*** 78.58
Group5 Ranitidine (10 mg/kg) 2.426±0.52*** 2.89±0.03*** 5.30±0.31*** 6.69±0.06*** 82.89
  1. MeOH PF= methanol extract of Paederia foetida; n=5; Data = Mean±SEM; αααP<0.001 (G1 Vs G2); ***P<0.001, (Group 2 Vs Group 3, 4 & 5)