Table 2 Subacute effect of carob pods aqueous extract (CPAE), famotidine (FAM) and ascorbic acid (AA) on macroscopic quantitative changes induced by EtOH in rats: ulcer mucus volume, ulcer area and percentage protection. Animals were pre-treated with various doses of CPAE (500, 1000 and 2000 mg/kg, b.w., p.o.), FAM (10 mg/kg, b.w., p.o.) or bi-distilled water, challenged with a single oral administration of EtOH (4 g/kg, b.w., p.o.) or NaCl 9‰ for two hours
Group | Mucus volume (ml) | Ulcer index (mm2) | Protection percentage (%) |
|---|---|---|---|
Control | 4.3 ± 0.20 | ---- | ---- |
EtOH | 1.9 ± 0.3* | 86.2 ± 2.6* | 00 |
EtOH + CPAE-500 | 2.9 ± 0 | 67.0 ± 3.6# | 23.4 |
EtOH + CPAE-1000 | 3.4 ± 0.2# | 16.6 ± 1.4# | 79.8 |
EtOH + CPAE-2000 | 3.9 ± 0.3# | 06.4 ± 0.9# | 92.2 |
EtOH + FAM | 3.8 ± 0.2# | 26.2 ± 3.3# | 68.1 |