Skip to main content

Table 3 Chromosomal aberration assay and relative cell counts of ORSE

From: Genotoxicity evaluation of Oryeong-san water extract using in vitro and in vivo tests

Nominal conc. of ORSE (μg/mL) S9 mix Time hours a) Mean total aberrant metaphases Mean total aberrations Mean of PP + ER Relative cell counts (%)
6 h treatment (+S9)       
 0 + 6–18 2.0/1.0 2.0/1.0 1.0 + 0.0 100
 1250 + 6–18 0.0/0.0 0.0/0.0 1.0 + 0.5 108
 2500 + 6–18 0.5/0.5 0.5/0.5 0.0 + 0.0 107
 5000 + 6–18 1.5/1.5 1.5/1.5 0.0+ 0.0 103
 CPA 6 + 6–18 25.5/25.5** 36.0/36.0 0.5 + 0.0 78
6 h treatment (-S9)       
 0 - 6–18 0.0/0.0 0.0/0.0 0.5 + 0.0 100
 1250 - 6–18 0.0/0.0 0.0/0.0 0.0 + 0.0 103
 2500 - 6–18 1.0/1.0 1.0/1.0 0.0 + 0.0 103
 5000 - 6–18 0.5/0.5 0.5/0.5 1.5 + 0.0 93
 EMS 800 - 6–18 28.5/28.5** 36.0/36.0 0.0 + 0.0 64
22 h treatment (-S9)       
 0 - 22-2 0.0/0.0 0.0/0.0 1.0 + 0.0 100
 1250 - 22-2 0.5/0.5 1.0/1.0 0.0 + 0.0 103
 2500 - 22-2 0.0/0.0 0.0/0.0 0.0 + 0.0 102
 5000 - 22-2 0.0/0.0 0.0/0.0 0.0 + 0.0 70
 EMS 600 - 22-2 33.0/33.0** 46.5/46.5 0.5 + 0.0 58
  1. **Significantly different from the control at P<0.01
  2. a) Treatment time-recovery time