Fig. 1

Prostate cancer spheroids respond to Arum paleastinum Boiss and the fortified GZ17. a Prostate cancer cells grown in 3D spheroids responded to Arum palaestinum Boiss and the fortified version, GZ17, in a dose dependent manner. GZ17 was more potent at inducing cell death compared to the plant extract with statistically lower cell numbers at 3.13 and 6.25 mg/ml. b Compared to the vehicle, which had no cell death effect, GZ17 was statistically more potent at inducing cell death. c The 3 fortifying components that when added to Arum palaestinum, create GZ17, were tested alone on prostate cells. The additives (open circles) had little effect on cell viability. *indicates p < 0.005; **indicates p < 0.001