|
Antibioticsa
|
Extract concentrations
|
MDR Bacteria used
|
% Modulating effectb
|
|---|
|
E. coli
|
E. aerogenes
|
K. pneumoniae
|
P. stuartii
|
P. aeruginosa
|
|---|
|
AG100
|
AG102
|
AG100Tet
|
CM64
|
EA289
|
EA298
|
K24
|
NEA16
|
PA124
|
|---|
|
AMP
|
0
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
| |
|
MIC/2
|
-(NA)
|
-(NA)
|
-(NA)
|
-(NA)
|
-(NA)
|
-(NA)
|
-(NA)
|
-(NA)
|
-(NA)
|
0
|
|
MIC/4
|
-(NA)
|
-(NA)
|
-(NA)
|
-(NA)
|
-(NA)
|
-(NA)
|
-(NA)
|
-(NA)
|
-(NA)
|
0
|
|
CHL
|
0
|
8
|
32
|
64
|
256
|
128
|
64
|
64
|
64
|
64
| |
|
MIC/2
|
8(1)
|
16 (2)
|
32(2)
|
256(1)
|
64(2)
|
8(8)
|
64(1)
|
16(4)
|
32(2)
|
66.65
|
|
MIC/4
|
8(1)
|
32(1)
|
64(1)
|
256(1)
|
64(2)
|
32(2)
|
64(1)
|
32(2)
|
32(2)
|
44.44
|
|
CIP
|
0
|
≤0.5
|
≤0.5
|
128
|
64
|
128
|
1
|
128
|
1
|
32
| |
|
MIC/2
|
≤0.5(NA)
|
≤0.5
|
64(2)
|
64(1)
|
128(1)
|
1(1)
|
64(2)
|
1(1)
|
16(2)
|
33.33
|
|
MIC/4
|
≤0.5(NA)
|
≤0.5
|
64(2)
|
64(1)
|
128(1)
|
1(1)
|
64(2)
|
1(1)
|
16(2)
|
33.33
|
|
NFX
|
0
|
≤0.5
|
≤0.5
|
256
|
-
|
128
|
8
|
-
|
4
|
128
| |
|
MIC/2
|
≤0.5(NA)
|
≤0.5
|
128(2)
|
64(>4)
|
128(1)
|
8(1)
|
-(NA)
|
4(1)
|
64(2)
|
33.33
|
|
MIC/4
|
≤0.5(NA)
|
≤0.5
|
256(1)
|
64(>4)
|
128(1)
|
8(1)
|
-(NA)
|
4(1)
|
64(2)
|
22.22
|
|
KAN
|
0
|
64
|
4
|
8
|
2
|
16
|
32
|
4
|
16
|
128
| |
|
MIC/2
|
4(16)
|
4(1)
|
4(2)
|
≤0.5(>4)
|
2(8)
|
32(1)
|
2(2)
|
4(4)
|
64(2)
|
77.78
|
|
MIC/4
|
8(8)
|
4(1)
|
4(2)
|
1(2)
|
4(4)
|
32(1)
|
2(2)
|
8(2)
|
64(2)
|
77.78
|
|
STR
|
0
|
>64
|
-
|
-
|
4
|
16
|
32
|
4
|
32
|
64
| |
|
MIC/2
|
>64(NA)
|
256 (≥2)
|
4(>64)
|
1(4)
|
4(4)
|
16(2)
|
1(4)
|
8(4)
|
32(2)
|
88.89
|
|
MIC/4
|
>64(NA)
|
-
|
128(>2)
|
2(2)
|
4(4)
|
32(1)
|
2(2)
|
16(2)
|
32(2)
|
66.67
|
|
ERY
|
0
|
32
|
64
|
-
|
-
|
64
|
16
|
128
|
16
|
128
| |
|
MIC/2
|
8(4)
|
64(1)
|
256(>1)
|
-(NA)
|
64(1)
|
4(4)
|
128(1)
|
4(4)
|
64(2)
|
44.44
|
|
MIC/4
|
8(4)
|
64(1)
|
-(NA)
|
-(NA)
|
64(1)
|
16(1)
|
128(1)
|
8(2)
|
128(1)
|
22.22
|
|
TET
|
0
|
2
|
8
|
32
|
16
|
32
|
4
|
16
|
4
|
16
| |
|
MIC/2
|
≤0.5(>4)
|
2(4)
|
8(4)
|
4(4)
|
8(4)
|
2(2)
|
8(2)
|
2(2)
|
4(4)
|
100
|
|
MIC/4
|
1(2)
|
8(1)
|
32(1)
|
8(2)
|
8(4)
|
2(2)
|
8(2)
|
2(2)
|
4(4)
|
77.78
|
- a: Antibiotics (TET: tetracycline, KAN: kanamycin, STR: streptomycin, ERY: erythromycin, CHL: chloramphenicol, NFX: norfloxacin, CIP: ciprofloxacin, AMP: ampicillin; - : MIC not detected at up to 256 μg/mL; (): Modulation factor or gain of activity; b: Percentage of Antibiotic’s modulation Activity by the Plant extracts; Indications in bold represent the modulation factor ≥ 2, antibiotics having a percentage of modulating effect greather than 50 %; NA: Not applicable
