Skip to main content

Table 4 Antinociceptive effect of the constituent plant extracts of Nefang on electric heat-induced pain on the tails of mice

From: Pharmacological evidence for the folk use of Nefang: antipyretic, anti-inflammatory and antinociceptive activities of its constituent plants

Treatment (Drug/Aqueous Extract) Dose (mg/kg) Tail flick reaction time [RT] (sec) and pain inhibition [PI] (%) at designated time intervals (minutes) (x ± SD, n = 5)
   0 30   60   90   120  
   RT RT PI RT PI RT PI RT PI
Paracetamol 150 4.27 ± 0.38 6.82 ± 0.28 60.0 8.39 ± 0.20 96.8 8.43 ± 0.36 97.6 8.26 ± 0.23 93.5
Mangifera indica bark 300 4.30 ± 0.38 5.62 ± 0.24 31.7 6.47 ± 0.37 51.7 6.30 ± 0.31* 47.6 5.66 ± 0.24* 32.7
600 4.30 ± 0.38 5.96 ± 0.49 39.6 6.46 ± 0.37* 51.5 6.35 ± 0.25* 48.8 6.25 ± 0.20* 46.5
1200 4.30 ± 0.38 7.20 ± 0.27 68.8 8.05 ± 0.41 88.7 6.99 ± 0.29 63.8 6.98 ± 0.06 63.6
Mangifera indica leaf 300 4.32 ± 0.38 6.47 ± 0.25 51.8 7.59 ± 0.43 77.9 6.19 ± 0.37* 45.1 6.08 ± 0.20* 42.6
600 4.32 ± 0.38 6.95 ± 0.14 62.9 7.80 ± 0.21 82.2 7.78 ± 0.76 82.4 7.47 75.1
1200 4.32 ± 0.38 7.09 ± 0.48 66.1 8.89 ± 0.41 108.5 8.64 ± 0.44 102.6 8.42 ± 0.36 97.3
Psidium guajava leaf 300 4.25 ± 0.38 6.32 ± 0.35 49.3 6.49 ± 0.29 52.2 6.38 ± 0.17* 49.6 5.26 ± 0.17* 23.2
600 4.25 ± 0.38 7.63 ± 0.38 78.8 7.73 ± 0.27 81.2 7.42 ± 0.46 73.8 6.45 ± 0.31* 51.2
1200 4.25 ± 0.38 7.82 ± 0.35 83.3 7.88 ± 0.19 84.7 7.54 ± 0.37 76.7 7.08 ± 0.05 65.9
Carica papaya leaf 300 4.29 ± 0.38 5.80 ± 0.70* 36.1 6.35 ± 0.31* 48.9 6.19 ± 0.53* 45.1 5.98 ± 0.17* 40.2
600 4.29 ± 0.38 6.73 ± 0.87 57.8 6.65 ± 0.52 55.8 6.34 ± 0.48* 48.7 6.16 ± 0.27* 44.4
1200 4.29 ± 0.38 5.04 ± 0.62* 18.2 5.12 ± 0.39* 20.1 5.39 ± 0.63* 26.3 5.36 ± 0.29* 25.7
Cymbopogon citratus leaf 300 4.31 ± 0.38 5.42 ± 0.50* 27.0 6.22 ± 0.28* 45.8 5.48 ± 0.09 28.4 5.00 ± 0.38* 17.3
600 4.31 ± 0.38 6.00 ± 0.90 40.6 6.43 ± 0.33 50.8 5.98 ± 0.30* 40.1 5.74 ± 0.38* 34.5
1200 4.31 ± 0.38 5.87 ± 0.32 37.6 6.56 ± 0.41 53.7 5.80 ± 0.25* 36.0 5.69 ± 0.32* 33.4
Citrus sinensis leaf 300 4.27 ± 0.38 4.76 ± 0.17* 11.6 4.77 ± 0.31** 11.7 4.61 ± 0.32** 8.0 4.30 ± 0.22** 0.9
600 4.27 ± 0.38 4.92 ± 0.28* 15.4 4.59 ± 0.33** 7.5 4.65 ± 0.42** 9.1 4.35 ± 0.15** 1.9
1200 4.27 ± 0.38 4.55 ± 0.30* 6.7 4.35 ± 0.24** 1.9 4.38 ± 0.15** 2.8 4.26 ± 0.22** 0.0
Ocimum gratissimum leaf 300 4.33 ± 0.38 5.58 ± 0.38 30.8 6.33 ± 0.50* 48.5 6.45 ± 0.26* 51.2 5.85 ± 0.14* 37.0
600 4.33 ± 0.38 6.03 ± 0.76 41.3 6.60 ± 0.54 54.7 7.09 ± 0.68 66.1 6.19 ± 0.30* 45.1
1200 4.33 ± 0.38 7.50 ± 0.55 75.9 7.81 ± 0.29 83.0 9.09 ± 0.69 113.0 7.91 ± 0.38 85.5
  1. Significant difference * - p < 0.05, ** - p < 0.001 when compared to the standard control