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Table 1 Effect of AHM and its fraction on brewer’s yeast-induced pyrexia

From: Antipyretic, anti-inflammatory and analgesic activity of Acacia hydaspica R. Parker and its phytochemical analysis

Treatment Dose mg/kg Body temp. (N) Rectal temperature (°C)
After administration of drug
    After 24 h (T) 1 h (P1) 2 h (P2) 3 h (P3) 4 h (P4) 5 h (P5)
Saline 10 ml 36.96 ± 0.21 38.96 ± 0.02 38.88 ± 0.09 38.73 ± 0.03 38.62 ± 0.02 38.55 ± 0.06 38.5 ± 0.014
Paracetamol 100 37.36 ± 0.25 39.35 ± 0.21 38.70 ± 0.27 37.99 ± 0.07* 37.79 ± 0.04* 37.49 ± 0.02** 37.395 ± 0.02***
AHM 50 37.23 ± 0.12 39.03 ± 0.06 39.32 ± 0.12 38.47 ± 0.084 38.15 ± 0.05 37.91 ± 0.03 37.77 ± 0.14
100 36.85 ± 0.05 39.17 ± 0.08 39.05 ± 0.08 38.12 ± 0.021 37.94 ± 0.06 37.76 ± 0.05* 37.12 ± 0.03***
150 37.30 ± 0.1 39.53 ± 0.18 39.20 ± 0.14 38.05 ± 0.09*** 37.86 ± 0.04*** 37.62 ± 0.03* 37.36 ± 0.06***
AHE 50 37.19 ± 0.10 39.43 ± 0.54 38.82 ± 0.41 38.01 ± 0.014 37.99 ± 0.01 37.68 ± 0.045* 37.24 ± 0.239***
  100 36.85 ± 0.05 38.67 ± 0.44 38.6 ± 0.489 37.88 ± 0.03* 37.475 ± 0.324** 37.31 ± 0.19*** 36.75 ± 0.245***
  150 37.10 ± 0.10 39.18 ± 0.28 38.55 ± 0.45 37.62 ± 0.02** 37.625 ± 0.494** 37.195 ± 0.005*** 37.13 ± 0.12***
  1. Data values shown represent mean ± SEM (n = 6). *p < 0.05, **p < 0.01, ***p < 0.001 versus only brewer’s yeast treated group (Two-way ANOVA followed by Bonferroni multiple comparison test). N indicates mean body temperature before pyrexia.
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