SBS reduced the incidence and multiplicity of colonic neoplasms. (A) Microscopic view of colon in mice. (B) Effect of SBS on colonic neoplasms size. SBS significantly delayed tumor growth and reduced neoplasms size. Data were presented as mean ± SD. *P < 0.01 vs. model, #P < 0.05 vs. model. (C) Most of colorectal neoplasms were histologically consistent with tubular adenoma or adenocarcinoma. Histological studies were carried out based on haematoxylin and eosin (H&E) staining as described. (Ca) Normal colon; (Cb) tubular adenoma, (Cc) adenocarcinoma. 40× for all, scale bar = 100 μm.