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Table 2 Comparison of relative organ weights and biochemical parameters in DBA/1J mice with CIA

From: Brazilin isolated from Caesalpinia sappan L. inhibits rheumatoid arthritis activity in a type-II collagen induced arthritis mouse model

Groups (n = 10) Normal Control MTX Brazilin
Average relative organ weights (organ weight/body weight, %)
  Liver 4.93 ± 0.10 6.01 ± 0.48* 4.84 ± 0.62 6.03 ± 0.72
  Kidney 1.98 ± 0.11 1.95 ± 0.32 1.63 ± 0.11* 1.92 ± 0.13
  Spleen 0.25 ± 0.02 0.48 ± 0.14* 0.34 ± 0.10 0.56 ± 0.21
Biochemical parameters
  AST(U/L) 127.50 ± 29.10 172.50 ± 30.51 142.23 ± 30.17 145.00 ± 32.71
  ALT(U/L) 32.00 ± 2.83 44.50 ± 3.54* 43.33 ± 12.58 37.50 ± 3.54*
  Creatinine (mg/dL) 0.53 ± 0.11 0.70 ± 0.11 0.55 ± 0.05 0.55 ± 0.09
  1. Organ coefficients (liver, kidney, and spleen) for DBA/1J mice treated with saline, MTX (3 mg/kg of body weight; injected every third day from day 22 to day 42 after 2nd booster injection) or brazilin (10 mg/kg of body weight; injected daily from day 22 to day 42 after the 2nd booster injection). Statistical analysis was performed with a 2-sample t-test comparing each sample group to the related normal group. Note: *denotes statistical significance at p < 0.05 versus normal group.
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