Group | Dose | UA | UA inhibition | Liver XO | Liver XO inhibition |
---|---|---|---|---|---|
(mg/kg) | (μmol/L) | (%) | (U/per mg protein) | (%) | |
Normal | -- | 6.12 ± 2.12 | -- | 1.84 ± 0.15 | -- |
Model (YEP) | -- | 135.5 ± 29.2Δ | -- | 3.59 ± 0.28Δ | -- |
YEP + KD | 200 | 96.7 ± 27.8** | 28.6 | 3.05 ± 0.21* | 15.0 |
YEP + KD | 400 | 81.8 ± 22.9** | 39.6 | 2.65 ± 0.13* | 26.2 |
YEP + KD | 800 | 65.5 ± 15.9** | 51.6 | 2.15 ± 0.22** | 40.1 |
YEP + AP | 10 | 15.0 ± 3.0** | 88.9 | 1.28 ± 0.25** | 64.3 |
Normal | -- | 9.53 ± 1.42 | -- | 1.62 ± 0.23 | -- |
Model (PO) | -- | 243.1 ± 17.2Δ | -- | 3.86 ± 0.31Δ | -- |
PO + KD | 200 | 196.3 ± 22.8** | 19.2 | 3.15 ± 0.31 | 18.4 |
PO + KD | 400 | 162.5 ± 21.0** | 33.2 | 2.81 ± 0.13* | 27.2 |
PO + KD | 800 | 135.5 ± 15.6** | 44.3 | 2.65 ± 0.22* | 31.4 |
PO + AP | 10 | 25.0 ± 19.0** | 89.7 | 1.48 ± 0.15** | 61.7 |