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Table 2 Effect of Karapxa decoction (KD) or Allopurinol (AP) on serum uric acid (UA) and liver xanthine oxidase (XO) activity in yeast extract paste (YEP) and potassium oxonate (PO) models of hyperuricemic mice in vivo

From: Traditional Uighur Medicine Karapxa decoction, inhibits liver xanthine oxidase and reduces serum uric acid concentrations in hyperuricemic mice and scavenges free radicals in vitro

Group Dose UA UA inhibition Liver XO Liver XO inhibition
(mg/kg) (μmol/L) (%) (U/per mg protein) (%)
Normal -- 6.12 ± 2.12 -- 1.84 ± 0.15 --
Model (YEP) -- 135.5 ± 29.2Δ -- 3.59 ± 0.28Δ --
YEP + KD 200 96.7 ± 27.8** 28.6 3.05 ± 0.21* 15.0
YEP + KD 400 81.8 ± 22.9** 39.6 2.65 ± 0.13* 26.2
YEP + KD 800 65.5 ± 15.9** 51.6 2.15 ± 0.22** 40.1
YEP + AP 10 15.0 ± 3.0** 88.9 1.28 ± 0.25** 64.3
Normal -- 9.53 ± 1.42 -- 1.62 ± 0.23 --
Model (PO) -- 243.1 ± 17.2Δ -- 3.86 ± 0.31Δ --
PO + KD 200 196.3 ± 22.8** 19.2 3.15 ± 0.31 18.4
PO + KD 400 162.5 ± 21.0** 33.2 2.81 ± 0.13* 27.2
PO + KD 800 135.5 ± 15.6** 44.3 2.65 ± 0.22* 31.4
PO + AP 10 25.0 ± 19.0** 89.7 1.48 ± 0.15** 61.7
  1. KD: Karapxa decoction; YEP, yeast extract paste model; AP, allopurinol, PO: potassium oxonate model. Data represent mean ± S.E.M. of 10 animals.
  2. ΔP <0.05 compared to normal control group.
  3. *P < 0.05 compared to model control group.
  4. **P < 0.01 compared to model control group.
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