Mechanisms of gastroprotection of methanol extract of Melastoma malabathricum leaves

Table 2 Effects of the MEMM on gastric lesions induced by ethanol in rats pretreated with L- NAME or NEM

Pre-treatment	Treatment	Dose, mg/kg	Ulcer area (mm²)
Saline	10% DMSO	-	33.33 ± 1.84
	CBX	100	3.17 ± 0.31^a
	MEMM	500	0.83 ± 0.40^a
	Quercitrin	250 mg/kg	1.62 ± 0.74^a
L-NAME	10% DMSO	-	49.38 ± 3.64^b
	CBX	100 mg/kg	7.00 ± 0.76^ce
	MEMM	500 mg/kg	5.25 ± 0.98^cf
	Quercitrin	250 mg/kg	22.48 ± 1.93^cg
NEM	10% DMSO	-	61.50 ± 4.62^b
	CBX	100 mg/kg	12.00 ± 2.46^dh
	MEMM	500 mg/kg	54.33 ± 4.82^di
	Quercitrin	250 mg/kg	38.85 ± 5.21^dj

Values are mean ± SEM (n = 6 rats/group).
One-way ANOVA followed by Student–Newman–Keuls.
^a,bData differed significantly (p < 0.05) when compared to the (saline + 10% DMSO)- pretreated group.
^cData differed significantly (p < 0.05) when compared to the (L-NAME + 10% DMSO)- pretreated group.
^dData differed significantly (p < 0.05) when compared to the (NEM + 10% DMSO)- pretreated group.
^e,hData differed significantly (p < 0.05) when compared to the (saline + CBX)-pretreated group.
^f,iData differed significantly (p < 0.05) when compared to the (saline + MEMM)-pretreated group.
^g,jData differed significantly (p < 0.05) when compared to the (saline + quercitrin)-pretreated group.

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