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Table 2 Effect of TPEE on body weights and composition and biochemical parameters of S.D rats

From: Evaluation of anti-obesity activities of ethanolic extract of Terminalia paniculata bark on high fat diet-induced obese rats

Parameters NC HFD Orlistat TPEE (100) TPEE (150) TPEE (200)
Physiological parameters
† Food intake (g) 20 ± 0.8 24 ± 0.01 19 ± 0.10* 22 ± 0.04 21 ± 0.06* 21 ± 1.14*
‡ Body weight (g) 322.5 ± 14.2 510.8 ± 14.7a* 368 ± 9.1b* 481 ± 8.5NS 456.8 ± 10b* 413.6 ± 12b*
Lean Mass (g) 307.5 ± 11.2 405.5 ± 13.2a* 328 ± 6.8b* 400.7 ± 2.8NS 393.4 ± 10NS 371.2 ± 16b*
Total Fat (g) 15 ± 3.5 105.3 ± 12.8a* 39.6 ± 5.3b* 80.2 ± 8.9 NS 63.3 ± 4.1b* 42.4 ± 5.9b*
Fat Free Mass (g) 139.2 ± 4.5 178.45 ± 13.8a* 147.5 ± 4b* 176.5 ± 9.8NS 173.6 ± 8.9b* 164.7 ± 5.2b*
Fat (%) 4.6 ± 0.9 20.56 ± 1.3a* 10.7 ± 2.3b* 16.6 ± 4.5 NS 13.8 ± 1.2b* 10.2 ± 1.8b*
Anti- hyperglycemic index  
Glucose (mg/dl) 70.9 ± 3.4 153.2 ± 8.9a* 96.9 ± 6.2b* 130.9 ± 7.3NS 125 ± 6.5b* 102.4 ± 4.4b*
Insulin 2.2 ± 0.2 7.6 ± 0.8a* 5.2 ± 0.3b* 6.6 ± 0.4NS 6.2 ± 0.3b* 5.9 ± 0.2b*
Insulin resistance 3.3 ± 0.02 5.6 ± 0.01 4.4 ± 0.02 5.2 ± 0.04 4.9 ± 0.05 4.5 ± 0.04
Organ weights  
Liver (g) 9.5 ± 0.5 14.7 ± 0.8a* 11.7 ± 0.3b* 13.5 ± 0.5NS 12.3 ± 0.6 b* 11.1 ± 0.3b*
Retro peritoneal (g) 13.9 ± 0.8 4.6 ± 1.1b* 9.5 ± 0.7a* 7.8 ± 0.5NS 7.3 ± 0.6NS 5.2 ± 0.4b*
Mesenteric WAT (g) 1.8 ± 0.4 4.5 ± 0.3a* 2.1 ± 0.2b* 3.7 ± 0.5NS 3.1 ± 0.2b* 2.3 ± 0.2b*
Epididymal WAT (g) 4.1 ± 0.3 8.4 ± 0.5a* 4.4 ± 0.1b* 7.8 ± 0.6NS 7.0 ± 03NS 5.0 ± 0.1b*
Fecal weights and fecal lipids
Initial weight 1.0 ± 0.01 1.3 ± 0.102 1.3 ± 0.42 1.3 ± 0.26 1.3 ± 0.035 1.3 ± 1.20
Final weight 1.3 ± 0.24 1.9 ± 0.031a* 0.9 ± 0.18b* 1.2 ± 0.32NS 1.1 ± 0.02b* 0.98 ± 0.9b*
Fecal lipids (mg/g)
Initial level 7 ± 2.25 12 ± 1.23 12.5 ± 1.2 11.2 ± 1.6 13.2 ± 0.41 13.0 ± 1.02
Final level 9.8 ± 0.19 12.3 ± 1.2a* 16.1 ± 0.2b* 12.8 ± 2.5NS 14.2 ± 0.98b* 15.4 ± 1.08b*
  1. The data are given as mean ± S.D (n = 6). Values are statistically significant at *p < 0.05 aSignificantly different from control, bSignificantly different from HFD control, NC: Normal control group, HFD: High-fat diet group, TPEE: T. paniculata ethanolic extracts.
  2. The data is analyzed by parametric method-ANOVA.
  3. †: Weighed daily; ‡: Weighed weekly.