Parameters | NC | HFD | Orlistat | TPEE (100) | TPEE (150) | TPEE (200) |
---|---|---|---|---|---|---|
Physiological parameters | ||||||
†Food intake (g) | 20 ± 0.8 | 24 ± 0.01 | 19 ± 0.10* | 22 ± 0.04 | 21 ± 0.06* | 21 ± 1.14* |
‡ Body weight (g) | 322.5 ± 14.2 | 510.8 ± 14.7a* | 368 ± 9.1b* | 481 ± 8.5NS | 456.8 ± 10b* | 413.6 ± 12b* |
Lean Mass (g) | 307.5 ± 11.2 | 405.5 ± 13.2a* | 328 ± 6.8b* | 400.7 ± 2.8NS | 393.4 ± 10NS | 371.2 ± 16b* |
Total Fat (g) | 15 ± 3.5 | 105.3 ± 12.8a* | 39.6 ± 5.3b* | 80.2 ± 8.9 NS | 63.3 ± 4.1b* | 42.4 ± 5.9b* |
Fat Free Mass (g) | 139.2 ± 4.5 | 178.45 ± 13.8a* | 147.5 ± 4b* | 176.5 ± 9.8NS | 173.6 ± 8.9b* | 164.7 ± 5.2b* |
Fat (%) | 4.6 ± 0.9 | 20.56 ± 1.3a* | 10.7 ± 2.3b* | 16.6 ± 4.5 NS | 13.8 ± 1.2b* | 10.2 ± 1.8b* |
Anti- hyperglycemic index | Â | |||||
Glucose (mg/dl) | 70.9 ± 3.4 | 153.2 ± 8.9a* | 96.9 ± 6.2b* | 130.9 ± 7.3NS | 125 ± 6.5b* | 102.4 ± 4.4b* |
Insulin | 2.2 ± 0.2 | 7.6 ± 0.8a* | 5.2 ± 0.3b* | 6.6 ± 0.4NS | 6.2 ± 0.3b* | 5.9 ± 0.2b* |
Insulin resistance | 3.3 ± 0.02 | 5.6 ± 0.01 | 4.4 ± 0.02 | 5.2 ± 0.04 | 4.9 ± 0.05 | 4.5 ± 0.04 |
Organ weights | Â | |||||
Liver (g) | 9.5 ± 0.5 | 14.7 ± 0.8a* | 11.7 ± 0.3b* | 13.5 ± 0.5NS | 12.3 ± 0.6 b* | 11.1 ± 0.3b* |
Retro peritoneal (g) | 13.9 ± 0.8 | 4.6 ± 1.1b* | 9.5 ± 0.7a* | 7.8 ± 0.5NS | 7.3 ± 0.6NS | 5.2 ± 0.4b* |
Mesenteric WAT (g) | 1.8 ± 0.4 | 4.5 ± 0.3a* | 2.1 ± 0.2b* | 3.7 ± 0.5NS | 3.1 ± 0.2b* | 2.3 ± 0.2b* |
Epididymal WAT (g) | 4.1 ± 0.3 | 8.4 ± 0.5a* | 4.4 ± 0.1b* | 7.8 ± 0.6NS | 7.0 ± 03NS | 5.0 ± 0.1b* |
Fecal weights and fecal lipids | ||||||
Initial weight | 1.0 ± 0.01 | 1.3 ± 0.102 | 1.3 ± 0.42 | 1.3 ± 0.26 | 1.3 ± 0.035 | 1.3 ± 1.20 |
Final weight | 1.3 ± 0.24 | 1.9 ± 0.031a* | 0.9 ± 0.18b* | 1.2 ± 0.32NS | 1.1 ± 0.02b* | 0.98 ± 0.9b* |
Fecal lipids (mg/g) | ||||||
Initial level | 7 ± 2.25 | 12 ± 1.23 | 12.5 ± 1.2 | 11.2 ± 1.6 | 13.2 ± 0.41 | 13.0 ± 1.02 |
Final level | 9.8 ± 0.19 | 12.3 ± 1.2a* | 16.1 ± 0.2b* | 12.8 ± 2.5NS | 14.2 ± 0.98b* | 15.4 ± 1.08b* |