Table 1 Cytotoxicity of Mangifera pajang isolates against various cancer cell lines
From: Phytochemicals from Mangifera pajang Kosterm and their biological activities
Mangifera pajang | Cytotoxic activities (IC50μg/mL) | ||
|---|---|---|---|
MCF-7 | HeLa | HT-29 | |
Kernel (crude extracts) | |||
Petroleum ether | >30 | >30 | 5.51 ± 0.98 |
Chloroform | 15.60 ± 1.03 | >30 | 23.06 ± 0.75 |
Ethyl acetate | 3.99 ± 0.47 | 6.68 ± 0.46 | 14.40 ± 0.52 |
Methanol | 4.12 ± 0.20 | 5.40 ± 0.53 | 4.94 ± 0.36 |
Stem bark (crude extracts) | |||
Petroleum ether | 5.80 ± 0.23 | 11.8 ± 0.45 | 12.67 ± 0.82 |
Chloroform | 11.26 ± 1.08 | 17.48 ± 0.62 | 12.11 ± 0.39 |
Ethyl acetate | >30 | 29.84 ± 1.03 | 15.01 ± 0.52 |
Methanol | >30 | >30 | >30 |
Leaves (crude extracts) | |||
Petroleum ether | >30 | 23.78 ± 0.73 | 23.19 ± 0.31 |
Chloroform | >30 | >30 | >30 |
Ethyl acetate | >30 | >30 | >30 |
Methanol | 13.17 ± 0.49 | >30 | >30 |
Isolated compounds | |||
Methyl gallate (1) | 10.53 ± 0.29 | >30 | 18.07 ± 0.37 |
Mangiferonic acid (4) | >30 | 16.51 ± 0.55 | 18.03 ± 0.75 |
3β-hydroxy-cycloart-24-ene-26-oic acid (5) | 13.03 ± 0.81 | 6.27 ± 0.61 | >30 |
Lupeol (7) | 25.02 ± 0.71 | 13.09 ± 0.80 | >30 |
Lupenone (8) | 27.01 ± 0.34 | >30 | >30 |
Quercitrin (12) | 25.04 ± 0.72 | 11.93 ± 0.63 | 3.82 ± 0.91 |
*Standard | 3.36 ± 0.02 | 4.93 ± 0.51 | 2.04 ± 0.03 |