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Table 1 Cytotoxicity of Mangifera pajang isolates against various cancer cell lines

From: Phytochemicals from Mangifera pajang Kosterm and their biological activities

Mangifera pajang Cytotoxic activities (IC50μg/mL)
  MCF-7 HeLa HT-29
Kernel (crude extracts)    
Petroleum ether >30 >30 5.51 ± 0.98
Chloroform 15.60 ± 1.03 >30 23.06 ± 0.75
Ethyl acetate 3.99 ± 0.47 6.68 ± 0.46 14.40 ± 0.52
Methanol 4.12 ± 0.20 5.40 ± 0.53 4.94 ± 0.36
Stem bark (crude extracts)    
Petroleum ether 5.80 ± 0.23 11.8 ± 0.45 12.67 ± 0.82
Chloroform 11.26 ± 1.08 17.48 ± 0.62 12.11 ± 0.39
Ethyl acetate >30 29.84 ± 1.03 15.01 ± 0.52
Methanol >30 >30 >30
Leaves (crude extracts)    
Petroleum ether >30 23.78 ± 0.73 23.19 ± 0.31
Chloroform >30 >30 >30
Ethyl acetate >30 >30 >30
Methanol 13.17 ± 0.49 >30 >30
Isolated compounds    
Methyl gallate (1) 10.53 ± 0.29 >30 18.07 ± 0.37
Mangiferonic acid (4) >30 16.51 ± 0.55 18.03 ± 0.75
3β-hydroxy-cycloart-24-ene-26-oic acid (5) 13.03 ± 0.81 6.27 ± 0.61 >30
Lupeol (7) 25.02 ± 0.71 13.09 ± 0.80 >30
Lupenone (8) 27.01 ± 0.34 >30 >30
Quercitrin (12) 25.04 ± 0.72 11.93 ± 0.63 3.82 ± 0.91
*Standard 3.36 ± 0.02 4.93 ± 0.51 2.04 ± 0.03
  1. *MCF-7: Tamoxifen, HeLa: Cisplatin, HT-29: 5-Fluorouracil.
  2. IC50 > 30: Inactive, <10 μg/mL: highly active, 10 to 20 μg/mL: moderately active, 20 to 30 μg/mL: weakly active.