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Table 7 Exact MICs (μg/ml) of flavonoid/(s) with antibiotics against S. aureus (ATCC 43300) and clinical isolates of MRSA

From: Antibiotic additive and synergistic action of rutin, morin and quercetin against methicillin resistant Staphylococcus aureus

 

With (M + R)♣

With Q

With (M + R)♣ + Q

AMO†

340

260

(140)♣ + 80

AMO*

367.40 ± 15.71

279.00a ± 14.65

(163.56a)♣ ±16.75 + 103.56a ± (15.99)

MIC range*

340 - 380

260 - 320

M + R = 140 – 200; Q = 80 – 140

AMP†

400

160

(160)♣ + 80

AMP*

427.40a ± 14.40

178.80a ± 14.25

(186.56a)♣ ± 15.80 + 112.37a ± 16.42

MIC range*

400 - 440

160 - 200

M + R = 160–220; Q = 80 – 140

CEPH†

340

160

(140)♣ + 60

CEPH*

367.40 ± 15.71

178.80a ± 14.25

(163.56a)♣ ± 16.52 + 83.56a ±15.02

MIC range*

340 - 380

160 - 200

M + R = 140 – 200; Q = 60 – 120

CET †

320

140

(140) ♣ +40

CET*

347.40 ± 12.92

158.60a ± 15.11

(162.94a)♣ ± 16.98+ 65.94 a ± 16.9

MIC range*

320 - 360

140 - 180

M + R = 140 – 180; Q = 40 -100

IMP†

300

120

(120) ♣ +40

IMP*

327.80a ± 14.85

138.80a ± 14.99

(148.31a)♣ ± 19.59+ 66.56a ±16.50

MIC range*

300 - 340

120 - 160

M + R = 120–180 ; Q = 40 – 100

ME†

360

180

180 + 80

ME*

387.40 ± 15.78

196.70a ± 12.75

(208.51a)♣ ± 19.98 + 88.51a ±19.80

MIC range*

360 - 400

180 - 220

M + R = 180 – 240; Q = 80-160

  1. ♣MIC of M & R is same.
  2. a= Average value.
  3. *against MRSA clinical isolates (n = 100).
  4. † against S. aureus (ATCC 43300).