Table 3 The Network objects and its functions

1

Homo sapiens

ACPP

PPAP

Protein phosphatase

2

Homo sapiens

ADK

Adenosine kinase

Generic kinase

3

Homo sapiens

ARL5A

ARL5

RAS superfamily

4

Homo sapiens

BACE1

BACE1

Generic protease

5

Homo sapiens

C3

C3

Generic binding protein

C3a

Generic binding protein

C3b

Generic binding protein

C3c

Generic binding protein

C3dg

Generic binding protein

C5 convertase (C2aC4bC3b)

Generic protease

C5 convertase (C3bBb)

Generic protease

iC3b

Generic binding protein

6

Homo sapiens

CALM1

Calmodulin

Generic binding protein

7

Homo sapiens

CALM2

Calmodulin

Generic binding protein

8

Homo sapiens

CALM3

Calmodulin

Generic binding protein

9

Homo sapiens

CCNA2

Cyclin A

Generic binding protein

Cyclin A2

Generic binding protein

10

Homo sapiens

CDK2

CDK2

Protein kinase

11

Homo sapiens

CES1

CES1

Generic enzyme

12

Homo sapiens

EGF

EGF

Receptor ligand

13

Homo sapiens

EGFR

EGFR

Receptor with enzyme activity

14

Homo sapiens

FBXW7

Cul1/Rbx1 E3 ligase

Generic enzyme

FBXW7

Generic binding protein

Skp2/TrCP/FBXW

Generic binding protein

15

Homo sapiens

FNTA

FTase

Generic enzyme

FTase-alpha

Generic enzyme

GGTase-I

Generic enzyme

16

Homo sapiens

FNTB

FTase

Generic enzyme

FTase-beta

Generic enzyme

17

Homo sapiens

GLO1

Glyoxalase I

Generic enzyme

18

Homo sapiens

GSTA1

GSTA1

Generic enzyme

19

Homo sapiens

HBA1

Adult hemoglobin

Generic protein

Alpha1-globin

Transporter

HP/HB complex

Generic protein

20

Homo sapiens

HBA2

Adult hemoglobin

Generic protein

Alpha1-globin

Transporter

HP/HB complex

Generic protein

21

Homo sapiens

HBB

Adult hemoglobin

Generic protein

HBB

Transporter

HP/HB complex

Generic protein

22

Homo sapiens

HPGDS

PGDS

Generic enzyme

23

Homo sapiens

KIF11

KNSL1

Generic binding protein

24

Homo sapiens

NCBP1

CBP80

Generic binding protein

25

Homo sapiens

NCBP2

CBP20

Generic binding protein

26

Homo sapiens

NUP98

NUP98

Generic channel

NUP98/HHEX fusion protein

Transcription factor

NUP98/HOXA9 fusion protein

Transcription factor

Nuclear pore complex proteins

Generic channel

27

Homo sapiens

PAPSS2

PAPSS2

Generic kinase

28

Homo sapiens

PDE5A

PDE

Generic protein

PDE5A

Generic enzyme

29

Homo sapiens

PIK3CG

PI3K cat class IB (p110-gamma)

Lipid kinase

30

Homo sapiens

POLL

DNA polymerase lambda

Generic enzyme

31

Homo sapiens

PPIA

Cyclophilin A

Generic enzyme

32

Homo sapiens

PPP3CA

Calcineurin A (alpha)

Protein phosphatase

Calcineurin A (catalytic)

Protein phosphatase

33

Homo sapiens

PPP3R1

Calcineurin B (regulatory)

Generic binding protein

Calcineurin B1

Generic binding protein

34

Homo sapiens

PYGL

Glycogen phosphorylase

Generic enzyme

PYGL

Generic enzyme

35

Homo sapiens

RAC3

Rac3

RAS superfamily

36

Homo sapiens

SNRPA

SNRPA

Generic binding protein

37

Homo sapiens

TK1

TK1

Generic kinase

38

Homo sapiens

TOP1

TOP1

Generic enzyme

39

Homo sapiens

UPF1

RENT1

Generic binding protein

1

Rattus norvegicus

Ctsb

Cathepsin B

Generic protease

2

Rattus norvegicus

Fnta

FTase

Generic enzyme

FTase-alpha

Generic enzyme

GGTase-I

Generic enzyme

3

Rattus norvegicus

Fntb

FTase

Generic enzyme

FTase-beta

Generic enzyme

4

Rattus norvegicus

Grm1

Galpha(q)-specific metabotropic glutamate GPCRs

Generic receptor

mGluR1

GPCR

5

Rattus norvegicus

Nos1

nNOS

Generic enzyme

1

Mus musculus

Gsta1

Gsta1 (mouse)

Generic enzyme

2

Mus musculus

H2-D1

HLA-B

Generic receptor

MHC class I

Generic receptor

3

Mus musculus

H2-Ea

HLA-DRA1

Generic receptor

MHC class II

Generic receptor

MHC class II alpha chain

Generic receptor

4

Mus musculus

H2-Ea

HLA-DRA1

Generic receptor

MHC class II

Generic receptor

MHC class II alpha chain

Generic receptor

5

Mus musculus

H2-L

H-2 L(d)

Generic receptor

HLA-C

Generic receptor

MHC class I

Generic receptor

6

Mus musculus

Nos2

iNOS

Generic enzyme

7

Mus musculus

OTTMUSG00000015050

Trav9d-4

Generic receptor

8

Mus musculus

Polm

DNA polymerase mu

Generic enzyme

9

Mus musculus

Tpmt

Thiopurine S-methyltransferase

Generic enzyme

10

Mus musculus

Uap1

UAP1

Generic enzyme