Figure 4

Pathological changes visualized under TEM on Day 18 PI (scale bar 0.5 μm). NC mice showed normal structures, while EAE mice had large amounts of demyelination. PA- and BSYSC-treated EAE mice exhibited a lighter demyelination than EAE mice. The results were expressed as a total area of / diameter (mean) of myelin. Note: ^**p <0.01, ^***p <0.001 VS NC; ^#p <0.05, ^##p <0.01, ^###p <0.001 VS EAE.