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Table 1 In vitro trypanocidal activity and cytotoxicity of flavonoids from Vitex simplicifolia against T.b rhodesiense and L6 cells respectively

From: Evaluation of the in vitro trypanocidal activity of methylated flavonoid constituents of Vitex simplicifolia leaves

Compound T.b.rhodesiense L6 Cells SI
  IC50μg/ml IC50μg/ml  
1 10.2 100 9.8
2 12.3 6.64 0.5
3 13.8 14.0 1.0
4 19.4 28.2 1.4
5 23.7 100 4.2
6 4.7 46.2 9.8
7 10.8 1.58 0.2
Melarsoprol 0.002   
Podophyllotoxin   0.005  
  1. SI: selectivity index (IC50 of L6 cells/ IC50 of T.b.rhodesiense).