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Table 1 In vitro trypanocidal activity and cytotoxicity of flavonoids from Vitex simplicifolia against T.b rhodesiense and L6 cells respectively

From: Evaluation of the in vitro trypanocidal activity of methylated flavonoid constituents of Vitex simplicifolia leaves

Compound

T.b.rhodesiense

L6 Cells

SI

 

IC50μg/ml

IC50μg/ml

 

1

10.2

100

9.8

2

12.3

6.64

0.5

3

13.8

14.0

1.0

4

19.4

28.2

1.4

5

23.7

100

4.2

6

4.7

46.2

9.8

7

10.8

1.58

0.2

Melarsoprol

0.002

  

Podophyllotoxin

 

0.005

 
  1. SI: selectivity index (IC50 of L6 cells/ IC50 of T.b.rhodesiense).
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BMC Complementary Medicine and Therapies

ISSN: 2662-7671

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