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Table 1 Effect of leaf extract of P. hydropiper extract in hot plate test

From: Antinociceptive effect of methanol extract of leaves of Persicaria hydropiper in mice

Treatment Dose (mg/kg) Latency period (in sec) (% MPE)
Pretreatment 30 min 60 min 90 min 120 min
Control 0.1 ml/mouse 5.97 ± 0.29 6.98 ± 0.32 7.23 ± 0.07 7.88 ± 0.19 9.08 ± 0.21
Morphine 5 6.94 ± 0.62 11.93 ± 0.17*(38.20) 13.34 ± 0.40*(17.47) 15.01 ± 0.08*(25.07) 15.95 ± 0.17* (18.83)
MEPH 25 5.80 ± 0.19 6.86 ± 0.24(11.93) 7.11 ± 0.17(1.90) 7.87 ± 0.20(5.89) 8.08 ± 0.11*(1.73)
MEPH 50 5.98 ± 0.19 6.39 ± 0.10(2.92) 7.80 ± 0.09(10.36) 8.33 ± 0.08(4.35) 10.15 ± 0.05*(15.59)
MEPH 75 6.55 ± 0.82 8.83 ± 0.05*(21.41) 10.26 ± 0.05*(12.80) 12.61 ± 0.08*(24.13) 14.07 ± 0.04*(19.76)
NLX 2 12.79 ± 0.26 10.09 ± 0.06 7.79 ± 0.20 6.85 ± 0.12 5.85 ± 0.19
NLX + Control 2 + 0.1 ml/mouse 5.82 ± 0.29 7.26 ± 0.08 7.66 ± 0.09 8.01 ± 0.08 9.44 ± 0.05
NLX + Morphine 2 + 5 7.29 ± 0.42 7.35 ± 0.58a(0.47) 8.21 ± 0.26a(6.79) 8.95 ± 0.21a (6.27) 9.13 ± 0.08a(1.62)
NLX + MEPH 2 + 25 5.78 ± 0.21 6.07 ± 0.28b(2.03) 7.49 ± 0.07(10.23) 8.01 ± 0.13b(4.15) 9.09 ± 0.14b(9.00)
NLX + MEPH 2 + 50 5.98 ± 0.17 6.35 ± 0.08c(2.63) 7.80 ± 0.18(10.62) 8.24 ± 0.08c(3.60) 9.23 ± 0.04c(8.41)
NLX + MEPH 2 + 75 6.17 ± 0.16 7.05 ± 0.24d(6.36) 8.24 ± 0.04(9.18) 8.62 ± 0.06d(3.23) 9.43 ± 0.03d(7.16)
  1. Each value is presented as the mean ± SEM (n = 5). MEPH = Methanolic extract of P. hydropiper leaves; NLX = Naloxone.
  2. *p < 0.001 compared with the control group (Dunnett’s test).
  3. ap < 0.001 compared with the morphine group (Bonferroni’s test).
  4. bp < 0.05 compared with the MEPH 25 group (Bonferroni’s test).
  5. cp < 0.05 compared with the MEPH 50 group (Bonferroni’s test).
  6. dp < 0.01 compared with the MEPH 75 group (Bonferroni’s test).