Table 1 Effect of leaf extract of P. hydropiper extract in hot plate test

Control

0.1 ml/mouse

5.97 ± 0.29

6.98 ± 0.32

7.23 ± 0.07

7.88 ± 0.19

9.08 ± 0.21

Morphine

5

6.94 ± 0.62

11.93 ± 0.17*(38.20)

13.34 ± 0.40*(17.47)

15.01 ± 0.08*(25.07)

15.95 ± 0.17* (18.83)

MEPH

25

5.80 ± 0.19

6.86 ± 0.24(11.93)

7.11 ± 0.17(1.90)

7.87 ± 0.20(5.89)

8.08 ± 0.11*(1.73)

MEPH

50

5.98 ± 0.19

6.39 ± 0.10(2.92)

7.80 ± 0.09(10.36)

8.33 ± 0.08(4.35)

10.15 ± 0.05*(15.59)

MEPH

75

6.55 ± 0.82

8.83 ± 0.05*(21.41)

10.26 ± 0.05*(12.80)

12.61 ± 0.08*(24.13)

14.07 ± 0.04*(19.76)

NLX

2

12.79 ± 0.26

10.09 ± 0.06

7.79 ± 0.20

6.85 ± 0.12

5.85 ± 0.19

NLX + Control

2 + 0.1 ml/mouse

5.82 ± 0.29

7.26 ± 0.08

7.66 ± 0.09

8.01 ± 0.08

9.44 ± 0.05

NLX + Morphine

2 + 5

7.29 ± 0.42

7.35 ± 0.58^a(0.47)

8.21 ± 0.26^a(6.79)

8.95 ± 0.21^a (6.27)

9.13 ± 0.08^a(1.62)

NLX + MEPH

2 + 25

5.78 ± 0.21

6.07 ± 0.28^b(2.03)

7.49 ± 0.07(10.23)

8.01 ± 0.13^b(4.15)

9.09 ± 0.14^b(9.00)

NLX + MEPH

2 + 50

5.98 ± 0.17

6.35 ± 0.08^c(2.63)

7.80 ± 0.18(10.62)

8.24 ± 0.08^c(3.60)

9.23 ± 0.04^c(8.41)

NLX + MEPH

2 + 75

6.17 ± 0.16

7.05 ± 0.24^d(6.36)

8.24 ± 0.04(9.18)

8.62 ± 0.06^d(3.23)

9.43 ± 0.03^d(7.16)