Evaluation of antitumor property of extracts and steroidal alkaloids from the cultivated Bulbus Fritillariae ussuriensis and preliminary investigation of its mechanism of action

Table 3 Organ weights index of the mice xenografted with S180 cells and LLC cells

Groups	Dose (mg/kg)	Growth of weight (g)	Organ indices (mg/g)
Groups	Dose (mg/kg)	Growth of weight (g)	Spleen	Thymus	Heart	Liver	Lung	Kidney
S180 tumor model
Control	-	4.08 ± 0.61	7.02 ± 0.70	2.24 ± 0.22	5.17 ± 0.40	63.71 ± 3.53	6.88 ± 0.52	13.01 ± 0.61
TAFU	20	2.36 ± 0.81^###	6.86 ± 0.20^##	2.43 ± 0.35^##	4.34 ± 0.12	63.28 ± 2.10^#	7.29 ± 0.37	13.00 ± 0.50
	40	2.84 ± 0.74^#	6.67 ± 0.17^##	1.98 ± 0.12^{*, #}	4.67 ± 0.20	56.04 ± 1.11^*	6.62 ± 0.21	12.29 ± 0.37
	80	2.45 ± 0.50^##	5.43 ± 0.11^{*, #}	1.84 ± 0.17^*	4.55 ± 0.30	58.50 ± 0.82	6.39 ± 0.45	12.88 ± 0.63
CTX	20	−1.82 ± 0.64^***	4.26 ± 0.16^***	1.30 ± 0.15^**	4.73 ± 0.18	52.72 ± 3.30^*	6.75 ± 0.39	12.81 ± 0.59
LLC tumor model
Control	-	0.64 ± 0.48	6.07 ± 0.91	1.57 ± 0.32	5.93 ± 0.48	57.54 ± 3.99	6.90 ± 0.52	13.63 ± 0.60
TAFU	20	0.58 ± 0.68^###	7.74 ± 0.57^##	1.25 ± 0.13^###	5.22 ± 0.32^#	58.69 ± 1.32^#	7.20 ± 0.33^*	12.54 ± 0.55
	40	0.37 ± 0.32^{*, ##}	7.53 ± 0.38^##	1.18 ± 0.04^##	5.25 ± 0.43^#	53.44 ± 1.20^#	7.33 ± 0.10	11.17 ± 0.22
	80	0.29 ± 0.50^{*, ##}	5.68 ± 0.82^#	1.09 ± 0.07^{*, ##}	4.86 ± 0.12^*	53.85 ± 4.96^#	6.87 ± 0.60^#	11.69 ± 0.40
CTX	20	−1.88 ± 0.71^***	4.05 ± 0.42^**	0.41 ± 0.05^***	4.38 ± 0.17^*	44.34 ± 3.59^*	6.80 ± 0.54	11.96 ± 0.62

The reported values are the means ± S.E.M. (n = 10). Significant differences compared with Control group were designated as ^*P < 0.05, ^**P < 0.01 and ^***P < 0.001; and those compared with CTX group as ^#P < 0.05, ^##P < 0.01 and ^###P < 0.001.