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Table 3 Organ weights index of the mice xenografted with S180 cells and LLC cells

From: Evaluation of antitumor property of extracts and steroidal alkaloids from the cultivated Bulbus Fritillariae ussuriensis and preliminary investigation of its mechanism of action

Groups

Dose (mg/kg)

Growth of weight (g)

Organ indices (mg/g)

Spleen

Thymus

Heart

Liver

Lung

Kidney

S180 tumor model

Control

-

4.08 ± 0.61

7.02 ± 0.70

2.24 ± 0.22

5.17 ± 0.40

63.71 ± 3.53

6.88 ± 0.52

13.01 ± 0.61

TAFU

20

2.36 ± 0.81###

6.86 ± 0.20##

2.43 ± 0.35##

4.34 ± 0.12

63.28 ± 2.10#

7.29 ± 0.37

13.00 ± 0.50

 

40

2.84 ± 0.74#

6.67 ± 0.17##

1.98 ± 0.12*, #

4.67 ± 0.20

56.04 ± 1.11*

6.62 ± 0.21

12.29 ± 0.37

 

80

2.45 ± 0.50##

5.43 ± 0.11*, #

1.84 ± 0.17*

4.55 ± 0.30

58.50 ± 0.82

6.39 ± 0.45

12.88 ± 0.63

CTX

20

−1.82 ± 0.64***

4.26 ± 0.16***

1.30 ± 0.15**

4.73 ± 0.18

52.72 ± 3.30*

6.75 ± 0.39

12.81 ± 0.59

LLC tumor model

Control

-

0.64 ± 0.48

6.07 ± 0.91

1.57 ± 0.32

5.93 ± 0.48

57.54 ± 3.99

6.90 ± 0.52

13.63 ± 0.60

TAFU

20

0.58 ± 0.68###

7.74 ± 0.57##

1.25 ± 0.13###

5.22 ± 0.32#

58.69 ± 1.32#

7.20 ± 0.33*

12.54 ± 0.55

 

40

0.37 ± 0.32*, ##

7.53 ± 0.38##

1.18 ± 0.04##

5.25 ± 0.43#

53.44 ± 1.20#

7.33 ± 0.10

11.17 ± 0.22

 

80

0.29 ± 0.50*, ##

5.68 ± 0.82#

1.09 ± 0.07*, ##

4.86 ± 0.12*

53.85 ± 4.96#

6.87 ± 0.60#

11.69 ± 0.40

CTX

20

−1.88 ± 0.71***

4.05 ± 0.42**

0.41 ± 0.05***

4.38 ± 0.17*

44.34 ± 3.59*

6.80 ± 0.54

11.96 ± 0.62

  1. The reported values are the means ± S.E.M. (n = 10). Significant differences compared with Control group were designated as *P < 0.05, **P < 0.01 and ***P < 0.001; and those compared with CTX group as #P < 0.05, ##P < 0.01 and ###P < 0.001.