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Table 2 PK parameter estimates of IDV before and after co-administration with AG (1 gram every 8 hours), n = 13

From: Pharmacokinetic and metabolic effects of American ginseng (Panax quinquefolius) in healthy volunteers receiving the HIV protease inhibitor indinavir

  IDV alone (Day 7)
GM (95%CI)
IDV + AG (Day 22)
GM (95%CI)
Day 7/Day 22
Geometric Mean Ratio
(90% CI)
C max (ng/mL) 5623 (4027–7853) 5633 (4908–6464) 1.00 (0.77–1.29)
C min (ng/mL) 61.97 (42.72–89.88) 62.78 (39.72–99.24) 1.00 (0.77–1.29)
t max (hours) 0.98 (0.7189–1.3403) 0.74 (0.5527–0.9870) 0.75 (0.53–1.06)
AUC 0–8 (ng·h/dL) 12171 (8628–17168) 10700 (8515–13649) 0.89 (0.72–1.08)