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Table 2 Effect of Momordica charantia extract on liver glycogen levels, glucose uptake by hemidiaphragm and glycogenolysis by liver of alloxan diabetic rats

From: An experimental evaluation of the antidiabetic and antilipidemic properties of a standardized Momordica charantia fruit extract

Oral treatment (n = 8)

Liver glycogen g/100 g

Glucose uptake by hemidiaphragm mg/100 mg

Glucose transfer by liver mg/g

Pancreas histoarchetechture necrotic changes & persistence of islets of Langerhans*

 

Mean ± SEM

Normal control

3.8 ± 0.4

16.0 ± 0.4

26.9 ± 0.4

0.3 ± 0.01

Diabetic control

1.0 ± 0.2#

4.7 ± 0.2#

42.6 ± 2.2#

3.6 ± 0.13

MCE (150 mg/kg)

1.6 ± 0.2b

8.1 ± 0.3a

17.9 ± 0.4a

2.9 ± 0.2

MCE (300 mg/kg)

1.7 ± 0.1a

15.9 ± 0.4a

15.6 ± 0.7a

1.9 ± 0.12

Glibenclamide 4 mg/kg

1.8 ± 0.1a

14.0± 0.3a

17.9 ± 0.8a

1.8 ± 0.18

  1. Significant difference of diabetic control from normal control: #P < 0.001
  2. Significant difference of treated groups from diabetic control: aP < 0.001, bP < 0.005,
  3. *Scoring system: 0 – Normal, 1 – very mild, 2 – mild, 3 – moderate, 4 – marked