Skip to main content

Table 3 Effect of naloxone on the anticonvulsant activity of Pasipay in PTZ-induced convulsion in mice

From: Anticonvulsant effects of aerial parts of Passiflora incarnata extract in mice: involvement of benzodiazepine and opioid receptors

Treatment (dose) Onset (sec) Duration (sec) Mortality protection (%)
Normal saline (10 ml/kg) 51.83 ± 64 12 ± 1.80 0
Naloxone (5 mg/kg) 10.66 ± 0.66 49.6 ± 4.34 0
Pasipay (0.4 mg/kg) 600 ± 0*** 0 ± 0*** 100
Pasipay+ Naloxone 125.4 ± 2.87*** 8.81 ± 2.64 40
  1. Normal saline and Pasipay were administered (i.p.) 30 min before the injection of PTZ (90 mg/kg, i.p.); Naloxone was administered 35 min before the injection of PTZ (90 mg/kg, i.p.); Values are the mean ± S.E.M. for 10 mice; *** p < 0.001, compared to saline group, Tukey-Kramer test.