|
Treatment (dose)
|
Onset (sec)
|
Duration (sec)
|
Mortality protection (%)
|
|---|
|
Normal saline (10 ml/kg)
|
51.83 ± 64
|
12 ± 1.80
|
0
|
|
Naloxone (5 mg/kg)
|
10.66 ± 0.66
|
49.6 ± 4.34
|
0
|
|
Pasipay (0.4 mg/kg)
|
600 ± 0***
|
0 ± 0***
|
100
|
|
Pasipay+ Naloxone
|
125.4 ± 2.87***
|
8.81 ± 2.64
|
40
|
- Normal saline and Pasipay were administered (i.p.) 30 min before the injection of PTZ (90 mg/kg, i.p.); Naloxone was administered 35 min before the injection of PTZ (90 mg/kg, i.p.); Values are the mean ± S.E.M. for 10 mice; *** p < 0.001, compared to saline group, Tukey-Kramer test.
