Table 1 Effects of Pasipay on PTZ-induced convulsion in mice
Treatment (dose) | Onset (sec) | Duration (sec) | Seizure protection (%) | Mortality protection (%) |
|---|---|---|---|---|
Normal saline (10 ml/kg) | 51.83 ± 64 | 12 ± 1.80 | 0 | 0 |
Diazepam (0.5 mg/kg) | 485.5 ± 74.97*** | 3.5 ± 2.21* | 80 | 90 |
Diazepam (1 mg/kg) | 600 ± 0*** | 0 ± 0*** | 100 | 100 |
Pasipay (0.05 mg/kg) | 56 ± 4.51 | 15.3 ± 4.48 | 0 | 0 |
Pasipay (0.1 mg/kg) | 112.66 ± 16.2 | 7.1 ± 2.5 | 10 | 50 |
Pasipay (0.2 mg/kg) | 137.6 ± 17.8*** | 7 ± 1.1 | 20 | 80 |
Pasipay (0.4 mg/kg) | 600 ± 0*** | 0 ± 0*** | 100 | 100 |