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Table 1 Effects of Pasipay on PTZ-induced convulsion in mice

From: Anticonvulsant effects of aerial parts of Passiflora incarnata extract in mice: involvement of benzodiazepine and opioid receptors

Treatment (dose) Onset (sec) Duration (sec) Seizure protection (%) Mortality protection (%)
Normal saline (10 ml/kg) 51.83 ± 64 12 ± 1.80 0 0
Diazepam (0.5 mg/kg) 485.5 ± 74.97*** 3.5 ± 2.21* 80 90
Diazepam (1 mg/kg) 600 ± 0*** 0 ± 0*** 100 100
Pasipay (0.05 mg/kg) 56 ± 4.51 15.3 ± 4.48 0 0
Pasipay (0.1 mg/kg) 112.66 ± 16.2 7.1 ± 2.5 10 50
Pasipay (0.2 mg/kg) 137.6 ± 17.8*** 7 ± 1.1 20 80
Pasipay (0.4 mg/kg) 600 ± 0*** 0 ± 0*** 100 100
  1. Normal saline, diazepam and Pasipay were administered i.p. 30 min before the injection of PTZ (90 mg/kg, i.p.); Values are the mean ± S.E.M. for 10 mice. *p < 0.05;*** p < 0.001, compared to saline group, Tukey-Kramer test.