|
Treatment (dose)
|
Onset (sec)
|
Duration (sec)
|
Seizure protection (%)
|
Mortality protection (%)
|
|---|
|
Normal saline (10 ml/kg)
|
51.83 ± 64
|
12 ± 1.80
|
0
|
0
|
|
Diazepam (0.5 mg/kg)
|
485.5 ± 74.97***
|
3.5 ± 2.21*
|
80
|
90
|
|
Diazepam (1 mg/kg)
|
600 ± 0***
|
0 ± 0***
|
100
|
100
|
|
Pasipay (0.05 mg/kg)
|
56 ± 4.51
|
15.3 ± 4.48
|
0
|
0
|
|
Pasipay (0.1 mg/kg)
|
112.66 ± 16.2
|
7.1 ± 2.5
|
10
|
50
|
|
Pasipay (0.2 mg/kg)
|
137.6 ± 17.8***
|
7 ± 1.1
|
20
|
80
|
|
Pasipay (0.4 mg/kg)
|
600 ± 0***
|
0 ± 0***
|
100
|
100
|
- Normal saline, diazepam and Pasipay were administered i.p. 30 min before the injection of PTZ (90 mg/kg, i.p.); Values are the mean ± S.E.M. for 10 mice. *p < 0.05;*** p < 0.001, compared to saline group, Tukey-Kramer test.
