Immunomodulation of murine collagen-induced arthritis by N, N-dimethylglycine and a preparation of Perna canaliculus

Table 1 Effect of Perna and DMG on CIA in rats

Group	Treatment (mg/kg/day)	Incidence (%)	Day of CIA Onset (day)	Paw Size (mm)
Control	N/A	58.3 (14/24)	18.7 ± 1.6	19.5 ± 3.8
Perna	100	16.6 (3/18)^a	19.5 ± 1.6	14.2 ± 0.7^a
DMG	100	29.6 (8/27)^a	20.4 ± 1.7	17.2 ± 3.0
Perna + DMG	100 + 100	22.2 (2/9)^a	20.5 ± 0.5	19.0 ± 1.4

Rats were treated as indicated and incidence, onset and average paw size were determined. Numbers are given as mean ± s.e.m. ^aindicates p < 0.05 compared to controls.

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