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Table 6 Experiment B: Carageenan edema and oral administration

From: Rat models of acute inflammation: a randomized controlled study on the effects of homeopathic remedies

Drug Paw volume increase over time (ml ± SD) and effect (% of negative control)
  1 hr   3 hr   5 hr   7hr  
Saline 0.39 ± 0.17   0.77 ± 0.16   0.63 ± 0.18   0.54 ± 0.16  
Apis D4 0.37 ± 0.11 -7 0.81 ± 0.11 +6 0.70 ± 0.20 +12 0.60 ± 0.15 +11
Apis D30 0.43 ± 0.11 +8 0.82 ± 0.11 +7 0.73 ± 0.17 +16 0.59 ± 0.13 +10
Lachesis D6 0.40 ± 0.12 +1 0.79 ± 0.19 +3 0.71 ± 0.18 +14 0.58 ± 0.17 +7
Lachesis D30 0.40 ± 0.17 +2 0.79 ± 0.19 +3 0.75 ± 0.19 +19 0.59 ± 0.21 +10
Phosphorus D6 0.40 ± 0.15 +1 0.80 ± 0.18 +4 0.70 ± 0.16 +11 0.59 ± 0.20 +10
Phosphorus D30 0.41 ± 0.16 +3 0.85 ± 0.23 +11 0.72 ± 0.21 +14 0.59 ± 0.18 +10
Indomethacin i.m. 0.30 ± 0.14 -24 0.48 ± 0.15 -38 0.52 ± 0.10 -18 0.43 ± 0.10 -20
  1. ANOVA results for measurements from 1 to 7 hrs since edema induction. Treatment: F(7,14) = 4.23, p = 0.0105; Time: (F(3,6) = 26.91, p = 0.0007; Treatment × time (different profiles over time between treatments): F(21,42) = 2.07, p = 0.1010; Replication × time (different profiles over time between replications): F(6,45) = 8.61, p < 0.0001; Replication × treatment × time (different profiles over time between replications and treatments): F(42,315) = 1.65, p = 0.0110.
  2. Bold characters denote significant comparisons (by Student t test) vs. Saline group corresponding for time since edema induction.