Anti-obesity effects of chikusetsusaponins isolated from Panax japonicus rhizomes

Table 3 Effects of total chikusetsusaponins and orlistat (a lipase inhibitor) on liver weight, hepatic triacylglycerol, and adipose tissue weight in mice fed a high-fat diet for 9 weeks.

	Animal No.	Liver weight (g/100 g body weight)	Hepatic triacylglycerol (μmol/g)	Parametrial adipose tissue weight (g)
Laboratory chow pellet	26	5.20 ± 0.46*	22.3 ± 2.3*	0.71 ± 0.1*
High-fat diet (HF)	26	6.35 ± 0.76	141.8 ± 21.8	1.59 ± 0.3
HF +
1% Total saponins	11	6.13 ± 0.79	101.5 ± 6.8*	0.87 ± 0.1*
HF +
3% Total saponin	11	5.79 ± 0.47*	83.3 ± 6.7*	0.74 ± 0.1*
HF + 0.012% Orlistat	15	4.00 ± 0.11*	101.1 ± 4.8*	2.03 ± 0.12

Values are means ± S.E. of 11 – 26 mice. *Significantly different from the high-fat diet group, P < 0.05.

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