Effects of chikusetsusaponins and orlistat (a lipase inhibitor) on body weight in mice fed a high-fat diet for 9 weeks. Open circles, normal groups; solid circles, high-fat diet groups; open squares, high-fat plus 1% total chikusetsusaponin diet groups; solid squares, high-fat plus 3% total chikusetsusaponin diet groups; solid triangle, high-fat plus 0.012% orlistat diet. Values are means ± S.E. of 11–26 mice. * Significantly different from the high-fat diet group, P < 0.05.