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Table 1 Percentage blood glucose reduction produced by C. roseus after oral administration in normal rabbits.

From: The juice of fresh leaves of Catharanthus roseus Linn. reduces blood glucose in normal and alloxan diabetic rabbits

Group
(n = 5)
Dose Initial Blood glucose (mg/dl) Percent blood glucose reduction
    4 6 8 10 12 16 18 20 24 (h)
Control --- 105.6 -3.1 ± 5.3 -2.4 ± 6.4 -0.4 ± 6.2 -3.6 ± 5.0 -6.9 ± 6.3 -4.5 ± 4.2 -0.4 ± 9.9 5.9 ± 1.5 -1.5 ± 4.6
C. roseus 0.50 ml/kg 99.2 11.5 ± 0.7* 16.7 ± 1.2* 15.3 ± 3.1 12.6 ± 2.4* 4.9 ± 8.0 4.6 ± 6.6 8.1 ± 2.1 8.9 ± 1.9 1.0 ± 4.4
C. roseus 0.75 ml/kg 101.4 13.9 ± 5.1* 17.1 ± 1.9* 19.5 ± 3.4* 19.7 ± 5.7* 22.8 ± 3.1** 27.0 ± 0.7*** 28.6 ± 0.4* 14.7 ± 6.2 4.3 ± 7.1
C. roseus 1.0 ml/kg 108.5 14.1 ± 3.3* 17.5 ± 3.2* 19.2 ± 2.6* 20.8 ± 6.1* 24.4 ± 4.4** 29.6 ± 4.2*** 30.7 ± 5.2* 31.9 ± 5.3** 30.0 ± 1.4***
Glibenclamide 40 μg/kg 104.2 25.5 ± 4.1** 29.7 ± 4.9** 31.9 ± 4.8** 29.8 ± 5.2** 28.3 ± 4.7** 23.1 ± 3.6** 21.9 ± 3.6 19.8 ± 5.4 17.3 ± 4.7
  1. Values are mean percent blood glucose reduction (± S.E.M.) of five animals. Significant difference from control at corresponding intervals: *p < 0.05, **p < 0.01, ***p < 0.001