Disc cartilage regeneration during 2 years of supplement intake. T2-weighted MR images of lumbar spine, made in September 1999 (start of supplement intake), 2000 and 2001. Note the increase of MRI signal of disc L3-4 (thick arrows) and disappearance of focal disc protrusion (thin arrow) of this disc. Note that the fully degenerated L4-5 disc remains unchanged. Upper panels and lower panels represent two consecutive images of planes 4 mm apart.