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Table 2 Effect of Paederia foetida Linn. on biochemical parameters in STZ-induced diabetic rats

From: Paederia foetida Linn. leaf extract: an antihyperlipidemic, antihyperglycaemic and antioxidant activity

S. No. Biochemical parameter Normal control Normal control + PF (500 mg/kg) STZ-Diabetic control STZ diabetes + PF I (100 mg/kg) STZ diabetes + PF II (250 mg/kg) STZ diabetes + PF III (500 mg/kg) STZ diabetes + Glibenclamide (10 mg/kg)
1 Fasting plasma glucose (mg/dL) 81.8 ± 0.201 79.8 ± 0.245 348.4 ± 2.781a 154.2 ± 1.812b 133.2 ± 0.861b 107.6 ± 1.749b 122 ± 1.844b
2 Fasting Plasma Insulin (μU/mL) 11.4 ± 0.509 11.4 ± 0.245 2.4 ± 0.453a 4.2 ± 0.373b 6.2 ± 0.374b 10.6 ± 0.438b 9.6 ± 0.123b
3 Glycated Heamoglobin (A1c) (%) 1.24 ± 0.092 1.24 ± 0.0812 4.86 ± 0.178a 3.96 ± 0.238b 2.82 ± 0.861b 1.52 ± 0.0431b 1.86 ± 0.093b
4 Hexokinase (μg/mg of tissue) 151 ± 3.24 150.6 ± 3.108 88.4 ± 1.806a 115.2 ± 1.497b 131 ± 1.643b 147.2 ± 1.281b 141.6 ± 2.088b
5 Glucose-6-Phosphatase (unit/mg of tissue) 8 ± 0.707 8 ± 0.717 14.4 ± 0.927a 13.4 ± 0.509b 11.4 ± 0.432b 8.4 ± 0.436b 9.8 ± 0.374b
6 Fructose-1-6-biphosphatase (unit/mg of tissue) 26.8 ± 1.241 27 ± 1.517 54.8 ± 1.281a 43 ± 1.871b 38.2 ± 1.497b 30 ± 0.707b 31 ± 0.431b
7 Total Cholesterol (mg/dL) 66.2 ± 1.715 66.8 ± 1.393 141.2 ± 2.634a 129.8 ± 1.53b 101.8 ± 1.934b 76.2 ± 2.01b 84 ± 2.302b
8 Triglycerides (mg/dL) 78 ± 1.975 78.2 ± 1.431 144.8 ± 3.04a 131 ± 1.789b 110.2 ± 1.828b 91 ± 1.703b 98 ± 1.265b
9 Total HDL Cholesterol (mg/dL) 57 ± 1.14 57 ± 0.124 25.4 ± 1.208a 39 ± 1.225b 44.4 ± 1.03b 51.6 ± 0.927b 53.4 ± 0.927b
10 Total LDL Cholesterol (mg/dL) 6.4 ± 0.18 6.8 ± 0.431 86.8 ± 0.818a 64.6 ± 0.053b 35.4 ± 0.538b 8.4 ± 1.121b 11 ± 0.742b
11 Total VLDL Cholesterol (mg/dL) 15.6 ± 0.295 15.72 ± 0.132 28.96 ± 0.608a 26.2 ± 0.375b 22 ± 0.365b 18.2 ± 0.253b 10.6 ± 0.341b
  1. Values are given as mean ± S.E.M. of six rats in each group. a(P <0.01) compared with the corresponding value for normal control animals (group I); b(P <0.01) compared with the corresponding value for diabetic control animals (group III); ns-non significant.