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Table 1 The IC 50 values of 22 Kampo prescriptions that demonstrated significant PTP1B inhibitory activity

From: Evaluation of 147 Kampo prescriptions as novel protein tyrosine phosphatase 1B (PTP1B) inhibitory agents

Kampo formula

IC50(μ Unit/mL)a)

Daiokanzoto*

4.1 (± 0.08)

Masiningan*

4.3 (± 0.05)

Tokakujokito

4.9 (± 0.05)

Keimakakuhanto

6.3 (± 0.03)

Choijokito*

6.6 (± 0.09)

Bofutsushosan*

8.9 (± 0.08)

Daisaikoto

9.4 (± 0.06)

Kumibinroto

9.7 (± 0.63)

Kakkonto

9.7 (± 0.09)

Keishikashakuyakudaioto

10.2 (± 0.23)

Daijokito*

10.7(± 0.04)

Eppikajutsuto

11.6 (± 0.20)

Jidabokuippo

13.2 (± 0.04)

Tsudosan

13.8 (± 0.18)

Daisaikotokyodaio

14.0 (± 0.46)

Maoto

15.7 (± 0.18)

Kakkonkajutsubuto

15.7 (± 0.23)

Intinkoto

17.0 (± 0.20)

Maobushisaishinto

19.2 (± 0.16)

Kakkontokasenkyusini

19.8 (± 0.52)

Junchoto*

25.7 (± 0.94)

Keishito

29.5 (± 0.34)

Rhei Rhizoma

0.7 (± 0.02)c)

Cannabisi Fructus

51.6 (± 2.87)c)

Ursolic acidb)

4.3 (± 0.1)d)

  1. The PTPlB inhibitory activity was significantly showed by 22 of the 147 Prescription Kampo Preparations. 22 prescriptions which showed high inhibitory activity calculate IC50 a)Values are presented as mean ± SD, n = 3, Unit means the weight of a given dose for one day. b)Positive control. c)IC50 in μg/mL. d)IC50 in μM. *These are classified into “Jyokito” and the medicine of relation in Chinese medicine.
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BMC Complementary Medicine and Therapies

ISSN: 2662-7671

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