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Table 2 Adverse events classified by organ system according to WHO Adverse Reaction Terminology

From: Characterization of hypersensitivity reactions reported among Andrographis paniculata users in Thailand using Health Product Vigilance Center (HPVC) database

System organ class No. (%) [n = 243]a Preferred term(n)
Skin and appendages disorders 126(51.85) Urticaria (37), rash maculo-papular (31), rash (18), pruritus (16), rash erythematous (8), dermatitis exfoliative (1), skin exfoliation (2), Steven Johnson syndrome (1), sweating increased (2), acute generalized exanthematous pustulosis (1), bullous eruption (1), eosinophillia (1), fixed eruption (1), stomatitis ulcerative (1), purpura allergic (1), flushing (1)
Body as a whole-general disorders 57(23.46) Face oedema (19), angioedema (4), anaphylactic shock(5), anaphylactic reaction (4), fatigue (6), oedema mouth (5), fever (3), chest pain (3), oedema (2), oedema periorbital (1), therapeutic response decreased (2), back pain (1), oedema peripheral(3), pain(1)
Gastrointestinal system disorders 22(9.05) Nausea (8), vomiting (4), abdominal pain (2), diarrhea (1), gastro-intestinal disorder non-specific (1), lipsdry (1), stomatitis (1), melaena (1), mouth dry (1)
Respiratory system disorders 15(6.17) Dyspnoea (6), coughing (6), bronchospasm (2), sputum increased (1)
Psychiatric disorders 8(3.29) Anorexia (4), somnolence (3), insomnia(1)
Central and peripheral nervous system disorders 7(2.88) Headache (3), dysaethesia (2), dizziness(2)
Musculoskeleton system disorders 3(1.23) Muscle weakness (2), paralysis (1)
Vascular (extra cardiac) disorders 1(0.41) Vasculitis (1)
Liver and biliary system disorders 1(0.41) Hepatitis(1)
Urinary system disorders 1(0.41) Urinary frequency (1)
Various 2(0.82) Anaesthesia local (1), anaesthesia mouth(1)
  1. aNumber of events from 106 case reports (some reports have more than one event).
  2. Bold indicates hypersensitivity reactions with critical term.
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