KSY delays tumor growth in both immunocompetent and immunocompromised mice. The MBT-2 cancer cells (1 × 106) were injected s.c. into the dorsum of mice. After 10 days, tumor-bearing mice were randomly grouped and treated with vehicle or indicated drugs using the treatment protocol described in Figure 1. The mean tumor volumes of treated mice on the indicated days are shown. (a) The C3-B model (n = 17-20 for each group); (b) The Nu-B model (n = 14 for each group). *indicates p < 0.05 versus the vehicle group.