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Table 3 Time-course effects of EA intervention on the expressions of Ang II, AT 1 R, and AT 2 R after MCAO as determined by immunohistochemistry assay (IOD)

From: Electroacupuncture improves cerebral blood flow and attenuates moderate ischemic injury via Angiotensin II its receptors-mediated mechanism in rats

Time h

Model group

EA group

 

AngII

AT1R

AT2R

AngII

AT1R

AT2R

1

2.139 ± 0.295※

2.768 ± 0.454※

1.912 ± 0.484

1.746 ± 0.336**

2.474 ± 0.428※*

2.373 ± 0.487**

2

2.200 ± 0.177※

2.777 ± 0.222※

1.952 ± 0.505

1.928 ± 0.268**

2.317 ± 0.409※**

2.501 ± 0.449※**

3

2.259 ± 0.215※

2.496 ± 0.145※

2.455 ± 0.297※

2.003 ± 0.287**

2.191 ± 0.553※*

2.780 ± 0.339※**

6

2.330 ± 0.528※

2.425 ± 0.396※

2.526 ± 0.632※

2.634 ± 0.474※**

1.956 ± 0.366※**

2.885 ± 0.583※*

9

2.667 ± 0.383※

2.379 ± 0.496※

2.599 ± 0.454※

2.901 ± 0.344※*

2.057 ± 0.438※*

3.117 ± 0.412※**

12

2.889 ± 0.257※

2.595 ± 0.281※

2.484 ± 0.533※

3.108 ± 0.193※*

2.351 ± 0.193※**

3.155 ± 0.443※**

15

2.773 ± 0.344※

2.604 ± 0.262※

2.661 ± 0.428※

3.226 ± 0.210※*

2.337 ± 0.475※*

3.346 ± 0.295※**

18

2.754 ± 0.245※

2.657 ± 0.280※

2.539 ± 0.618※

3.012 ± 0.308※**

2.448 ± 0.366※*

2.997 ± 0.594※*

21

2.376 ± 0.542※

2.744 ± 0.436※

2.400 ± 0.623※

2.669 ± 0.479※*

2.526 ± 0.257※*

2.882 ± 0.588※**

24

2.474 ± 0.463※

2.697 ± 0.321※

2.445 ± 0.494※

3.233 ± 0.335※**

2.365 ± 0.400※**

2.817 ± 0.513※*

  1. EA: Electroacupuncture; Ang II: Angiotensin II; AT1R: Ang II type 1 receptor; AT2R: Ang II type 2 receptor; ※ p < 0.05 vs the control group (values were 1.872 ± 0.331 for AngII, 2.037 ± 0.307 for AT1R, and 2.091 ± 0.451 for AT2R), * p < 0.05, ** p < 0.01 vs model group at the same time points.