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Table 2 AR, AGEs and COLO 320 inhibitory effects of Compounds 1–9 and kaempferol-3-O-β-D-glucopyranoside compared with Qu, AG and 5-Fu

From: Extracts and compounds with anti-diabetic complications and anti-cancer activity from Castanea mollissina Blume (Chinese chestnut)

Compounds IC50(μM)
AR AGEs COLO 320
1 14.83 ± 0.28 57.06 ± 7.54 >100
2 2.39 ± 0.20*** 28.73 ± 2.96 24.10 ± 3.26
3 1.83 ± 0.02*** 8.48 ± 1.43* 22.56 ± 4.51
4 1.22 ± 0.06*** 5.58 ± 0.48*** 3.53 ± 0.42**
5 0.43 ± 0.06*** 3.27 ± 0.09*** 2.86 ± 0.39**
6 0.63 ± 0.12*** 0.75 ± 0.21*** 2.43 ± 1.01**
kaempferol-3-O-glc 10.40 ± 0.18** 42.64 ± 3.73 58.84 ± 3.26
7 6.33 ± 1.10** 12.69 ± 5.17 10.07 ± 1.84*
8 0.46 ± 0.01*** 4.43 ± 0.36*** 5.49 ± 0.23*
9 1.73 ± 0.14*** 5.21 ± 0.75*** 3.67 ± 0.09**
Qu 12.35 ± 1.06   
AG   10.68 ± 1.06  
5-Fu    8.79 ± 2.57
  1. Data represent mean ± S.E.M. (n=3). IC50 of Compounds< IC50 of Positive Control (Qu, AG, 5-Fu): *** p < 0.01 vs Positive Control, ** p < 0.05 vs Positive Control, * p >0.05 vs Positive Control; IC50 of Compounds> IC50 of Positive Control (Qu, AG, 5-Fu): p > 0.05 vs Positive Control. p > 0.01 vs Positive Control.