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Figure 5 | BMC Complementary and Alternative Medicine

Figure 5

From: Activation of caspases and inhibition of ribosome biogenesis mediate antitumor activity of Chijongdan in A549 non-small lung cancer cells

Figure 5

Effect of Chijongdan on apoptotic and ribosome biogenesis related proteins was reversed by pancaspase inhibitor Z-VAD-FMK in A549 cells. (A) Effect of Chijongdan on ribosomal biogenesis related proteins in A549 cells. (B) Effect of pan-caspase inhibitor Z--VAD-FMK on the ability of Chijongdan to inhibit ribosomal biogenesis and induce apoptosis in A549 cells. A549 cells were treated with 100 μg/ml of Chijongdan and/or pan-caspase inhibitor Z--VAD-FMK for 24 h and Western blotting was performed for UBF, Fibrillarin and PARP as shown in Methods.

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