Table 2 Antinociceptive effect of methanolic extract of C. nurvala leaves, morphine, and reversal effect of naloxone in tail immersion test

Control

0.1 ml/mouse

1.78 ± 0.17

2.01 ± 0.19

2.44 ± 0.09

2.77 ± 0.30

2.93 ± 0.29

Morphine

5

1.62 ± 0.10

3.11 ± 0.37* (8.13)

3.95 ± 0.27* (12.66)

4.35 ± 0.28* (14.87)

4.17 ± 0.24 (13.88)

MECN

50

1.75 ± 0.11

2.13 ± 0.11 (2.13)

2.32 ± 0.04 (3.16)

2.79 ± 0.19 (5.70)

2.96 ± 0.06 (6.67)

MECN

100

1.91 ± 0.13

2.63 ± 0.33 (3.98)

3.06 ± 0.53 (6.36)

4.15 ± 0.59* (12.37)

4.28 ± 0.59* (13.08)

MECN

200

1.81 ± 0.14

3.03 ± 0.26* (6.67)

3.75 ± 0.17* (10.66)

4.26 ± 0.34* (13.46)

4.58 ± 0.26* (15.20)

NLX

2

1.91 ± 0.11

2.23 ± 0.17

2.29 ± 0.19

2.30 ± 0.17

2.22 ± 0.32

NLX + Control

2 + 0.1 ml/mouse

1.68 ± 0.15

1.97 ± 0.08

2.11 ± 0.10

2.14 ± 0.13

2.27 ± 0.16

NLX + Morphine

2 + 5

1.94 ± 0.18

2.08 ± 0.08 (0.80)

2.52 ± 0.05^a (3.26)

2.95 ± 0.14^a (5.64)

3.11 ± 0.11 (6.50)

NLX + MECN

2 + 50

1.91 ± 0.16

2.08 ± 0.07 (0.94)

2.11 ± 0.08 (1.12)

2.13 ± 0.32 (1.22)

2.20 ± 0.38 (1.61)

NLX + MECN

2 + 100

1.78 ± 0.11

2.10 ± 0.13 (1.75)

2.21 ± 0.11 (2.38)

2.32 ± 0.04^b (2.99)

2.71 ± 0.15 (5.12)

NLX + MECN

2 + 200

1.95 ± 0.11

2.20 ± 1.10 (1.38)

2.41 ± 0.14^c (2.56)

2.55 ± 0.07^c (3.33)

2.80 ± 0.06^c (4.69)