Dose–response curves of the immobility time in TST with respect to the control groups. (A) The positive reference group (fluoxetine, 20 mg/kg, p.o.) response was 0 for the antidepressant-like effects of rutin, hesperidin, and the fixed-ratio combination of rutin/hesperidin (75:21.5, w/w). (B) The consequent isobolograms. Data are expressed as mean ± S.E.M. (n = 10).