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Table 1 The behavior of mice treated with the essential oil of Foeniculum vulgare and reference compounds in the elevated plus maze model

From: Evaluation of anxiolytic activity of the essential oil of the aerial part of Foeniculum vulgare Miller in mice

Treatment

Dose, mg/kg

Number of entries (counts/5 min)

Time spent (sec/5 min)

  

Open arm

Closed arm

Total

Open arm

Closed arm

Center

Vehicle

-

3.17 ± 1.33

8.50 ± 2.59

11.67 ± 3.66

44.17 ± 20.19

137.83 ± 38.24

118.00 ± 41.25

FV

50

4.83 ± 1.72

6.83 ± 0.75

11.66 ± 1.37

68.00 ± 25.69

117.50 ± 46.78

114.50 ± 50.03

FV

100

7.50 ± 4.59

5.83 ± 3.31

13.66 ± 3.78

109.67 ± 48.64a*

99.83 ± 43.32

90.50 ± 33.59

FV

200

11.00 ± 5.48a*

8.00 ± 4.90

19.00 ± 9.87c*

112.67 ± 35.62a*

71.33 ± 37.17a*

119.00 ± 36.87

FV

400

4.01 ± 2.10

4.00 ± 1.4 a *

8.00 ± 2.76(b, d)*

87.50 ± 36.32

93.33 ± 35.27

119.17 ± 27.13

Diazepam

0.5

10.83 ± 9.06a*

6.50 ± 2.59

17.50 ± 8.53 c*

123.67 ± 50.67a**

67.33 ± 34.63a*

84.67 ± 44.23

  1. Data are presented as mean ± S.E.M, n = 6, *P < 0.05, **P < 0.01, aagainst control, bagainst 200 mg/kg, cagainst 400 mg/kg, dagainst diazepam; FV = Foeniculum vulgare essential oil.