Evaluation of the locomotor activity of Lac-FR. Number of crossings in the open-field test of animals treated with vehicle (10 ml/kg, i.p.), pentobarbital (35 mg/kg, i.p.), and Lac-FR (75, 100, and 300 mg/kg) (i.p.). Results expressed as mean ± S.E.M. of 6 animals for experimental groups. (ANOVA and Tukey’s test. ***p < 0.01).