Antidiabetic, renal/hepatic/pancreas/cardiac protective and antioxidant potential of methanol/dichloromethane extract of Albizzia Lebbeck Benth. stem bark (ALEx) on streptozotocin induced diabetic rats

Table 4 Effect of methanol/dichloromethane extract of Albizzia Lebbeck Benth. stem bark (ALEx) on body weight variation (grams) in normal & STZ induced diabetic treated rats

Groups	Time (h)
Groups	1st Day	45th Day
Normal rats (untreated with dimethylsulfoxide, [DMSO]) Group 1	245.6 ± 4.479	297 ± 2.408
Diabetic control (administered with Streptozotocin (STZ) Group 2	249.8 ± 3.625	217.2 ± 3.527
Diabetic control + (ALEx) (100 mg/kg body weight) Group 3	245.6 ± 1.965^ns	236 ± 2.702
Diabetic control + (ALEx) (200 mg/kg body weight) Group 4	247.4 ± 1.288	247.2 ± 2.417
Diabetic control + (ALEx) (300 mg/kg body weight) Group 5	247.2 ± 3.680	266 ± 0.7071
Diabetic control + (ALEx) (400 mg/kg body weight) Group 6	252.2 ± 2.245**	300 ± 0.5099**
Diabetic control + Glibenclamide (1 mg/kg b wt.) Group 7	249.8 ± 1.020	302 ± 0.7071***

The data are expressed as mean ± SEM. (n = number of animals in each group = 5). The comparisons were made by one way ANOVA followed by Dunnent’s test.
ns = non-significant, STZ = Streptozotocin.
**p < 0.001 is considered as very significant when compared to the control group (0 h).
***p < 0.001 is considered as extremely significant when compared to the control group (0 h).