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Table 7 Pro-inflammatory biomarker changes in Xuan Bai Cheng Qi and control groups before and after 10 - day treatment

From: Xuan Bai Cheng Qi formula as an adjuvant treatment of acute exacerbation of chronic obstructive pulmonary disease of the syndrome type phlegm-heat obstructing the lungs: a multicenter, randomized, double-blind, placebo-controlled clinical trial

Biomarkers XBCQa(n = 22) Controla(n = 16) Treatment effectd(95% CI; P- value)
  Day 1 (Baseline) Day 10 (End) Mean Dc Day 1 (Baseline) Day 10 (End) Mean D  
TNF - α (pg/mL) 20.34 (4.90) 4.92 (1.90) -15.42 (4.88) 18.90 (3.61) 6.47 (1.56) -12.43 (3.28)c -1.70 (-2.86, -0.54; .005)
IL - 2 (pg/mL) 129.72 (18.27) 53.50 (18.21) -76.23 (25.21) 129.54 (28.70) 84.10 (11.01) -45.43 (32.88)c -30.60 (-40.94, -20.25; < .001)
IL - 4 (pg/mL) 5.98 (1.49) 2.36 (0.56) -3.61 (1.78) 6.15 (1.36) 3.38 (1.25) -2.77 (1.70)c -1.02 (-1.65, -0.39; .002)
IL - 6 (pg/mL) 3.95 (0.80) 2.06 (0.53) -1.89 (0.95) 3.81 (0.94) 2.76 (0.67) -1.06 (0.48)c -0.74 (-1.20, -0.39; < .001)
IL - 8 (pg/mL) 18.33 (3.93) 9.09 (3.54) -9.24 (6.11) 18.01 (4.17) 14.92 (3.86) -3.08 (5.36)b -5.80 (-8.26, -3.34; < .001)
IL - 1β (pg/mL) 13.42 (2.12) 8.36 (1.02) -7.89 (12.27) 12.86 (1.98) 9.23 (1.54) -4.76 (8.97)c -0.94 (-1.78, -0.10; .029)
  1. Abbreviations: CI confidence interval, IL- 1β interleukin - 1 beta, IL - 2 interleukin - 2, IL - 4 interleukin - 4, IL - 6 interleukin - 6, IL - 8 interleukin - 8, Mean D mean difference, TNF - α tumor necrosis factor alpha, XBCQ Xuan Bai Cheng Qi.
  2. aData presented as mean (SD).
  3. b P < .05.
  4. c P < .01: change between pre - treatment and post - treatment (within group difference by paired t - test).
  5. dCovariance analysis estimate with 95% confidence interval for difference.