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Table 2 Plasma metabolites detected in the sham-operated and model animals 4 days after the operation

From: Plasma metabonomics study on Chinese medicine syndrome evolution of heart failure rats caused by LAD ligation

Metabolic pathway RT (min) Metabolites Sham-operated (×109) Model (×109) P value
TAC 19.60 Citric acid 1.06 ± 0.721 4.54 ± 1.282▲▲ 0.000
24.18 cAMP 0.20 ± 0.035 0.26 ± 0.036 0.033
Amino acid metabolism 6.90 Acetamide 0.43 ± 0.084 0.027 ± 0.066 0.001
8.01 Ethylbis(trimethylsilyl)amine 0.85 ± 0.025 0.52 ± 0.130 0.006
9.45 Alanine 0.90 ± 0.230 0.52 ± 0.122 0.000
10.91 L-Norvaline 0.83 ± 0.428 2.38 ± 0.0932▲▲ 0.000
11.67 L-Valine 0.18 ± 0.056 0.08 ± 0.046 0.002
11.97 Urea 4.75 ± 1.096 3.55 ± 0.829 0.022
13.14 Glycine 0.324 ± 0.068 0.69 ± 0.174▲▲ 0.000
14.11 L-Serine 1.95 ± 0.234 1.36 ± 0.301 0.003
16.15 L-Proline 0.42 ± 0.038 0.42 ± 0.045 0.941
Glucose metabolism 20.57 d-Glucose 22.78 ± 6.987 15.97 ± 3.549 0.013
20.91 d-Galactose 27.47 ± 7.200 14.28 ± 3.173 0.002
15.30 à-D-Glucopyranoside 0.27 ± 0.117 0.42 ± 0.137 0.026
20.95 glucitol 22.79 ± 0.683 0.00 ± 0.000 0.026
Fatty acid metabolism 8.77 Lactic acid 1.93 ± 0.319 1.36 ± 0.325 0.005
9.22 Acetic acid 0.24 ± 0.017 0.18 ± 0.139 0.009
14.80 Butanoic acid 0.47 ± 0.166 0.73 ± 0.192▲▲ 0.009
17.48 Dodecanoic acid 0.00 ± 0.000 0.70 ± 0.562▲▲ 0.001
21.73 Hexadecanoic acid 1.68 ± 0.640 2.86 ± 1.387 0.026
  23.54 Octadecanoic acid 4.03 ± 1.332 6.36 ± 1.847 0.017
  1. Note: increased significantly in model group, P < 0.05 compare with the Sham Group, ▲▲P < 0.01 compare with the Sham Group; decreased significantly in model group, P < 0.05 compare with the Sham Group, P < 0.01 compare with the Sham Group.