Plasma metabonomics study on Chinese medicine syndrome evolution of heart failure rats caused by LAD ligation

Table 2 Plasma metabolites detected in the sham-operated and model animals 4 days after the operation

Metabolic pathway	RT (min)	Metabolites	Sham-operated (×10⁹)	Model (×10⁹)	P value
TAC	19.60	Citric acid	1.06 ± 0.721	4.54 ± 1.282^▲▲	0.000
TAC	24.18	cAMP	0.20 ± 0.035	0.26 ± 0.036^▲	0.033
Amino acid metabolism	6.90	Acetamide	0.43 ± 0.084	0.027 ± 0.066^▽▽	0.001
	8.01	Ethylbis(trimethylsilyl)amine	0.85 ± 0.025	0.52 ± 0.130^▽▽	0.006
	9.45	Alanine	0.90 ± 0.230	0.52 ± 0.122^▽▽	0.000
	10.91	L-Norvaline	0.83 ± 0.428	2.38 ± 0.0932^▲▲	0.000
	11.67	L-Valine	0.18 ± 0.056	0.08 ± 0.046^▽▽	0.002
	11.97	Urea	4.75 ± 1.096	3.55 ± 0.829^▽	0.022
	13.14	Glycine	0.324 ± 0.068	0.69 ± 0.174^▲▲	0.000
	14.11	L-Serine	1.95 ± 0.234	1.36 ± 0.301^▽▽	0.003
	16.15	L-Proline	0.42 ± 0.038	0.42 ± 0.045	0.941
Glucose metabolism	20.57	d-Glucose	22.78 ± 6.987	15.97 ± 3.549^▽	0.013
	20.91	d-Galactose	27.47 ± 7.200	14.28 ± 3.173^▽▽	0.002
	15.30	à-D-Glucopyranoside	0.27 ± 0.117	0.42 ± 0.137^▲	0.026
	20.95	glucitol	22.79 ± 0.683	0.00 ± 0.000^▽	0.026
Fatty acid metabolism	8.77	Lactic acid	1.93 ± 0.319	1.36 ± 0.325^▽▽	0.005
	9.22	Acetic acid	0.24 ± 0.017	0.18 ± 0.139^▽▽	0.009
	14.80	Butanoic acid	0.47 ± 0.166	0.73 ± 0.192^▲▲	0.009
	17.48	Dodecanoic acid	0.00 ± 0.000	0.70 ± 0.562^▲▲	0.001
	21.73	Hexadecanoic acid	1.68 ± 0.640	2.86 ± 1.387^▲	0.026
	23.54	Octadecanoic acid	4.03 ± 1.332	6.36 ± 1.847^▲	0.017

Note: ^▲increased significantly in model group, P < 0.05 compare with the Sham Group, ^▲▲P < 0.01 compare with the Sham Group; ^▽decreased significantly in model group, P < 0.05 compare with the Sham Group, ^▽▽P < 0.01 compare with the Sham Group.

ISSN: 2662-7671