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Table 3 Linear regression analysis for lipid traits in the subgroups of constitutional types

From: Genetic loci associated with changes in lipid levels leading to constitution-based discrepancy in Koreans

    Combined KoGES KCMS
SNP (allele, gene) Trait* Subject n Effect (SE) [mg/dL] P-value n Effect (SE) [mg/dL] P-value n Effect (SE) [mg/dL] P-value
rs4149270 HDLC TE 2646 -0.717 (0.301) 0.0171 1821 -0.728 (0.371) 4.97 × 10-2 825 -0.695 (0.514) 0.177
(C>T, ABCA1)   NTE 2658 -1.144 (0.367) 1.82 × 10-3 1822 -1.173 (0.453) 9.60 × 10-3 836 -1.088 (0.627) 0.0802
rs10889353 TG TE 2656 -0.018 (0.008) 0.0233 1823 -0.020 (0.010) 4.35 × 10-2 833 -0.015 (0.014) 0.286
(A>C, ANGPTL3)   NTE 2658 -0.023 (0.008) 2.33 × 10 -3 1824 -0.022 (0.010) 2.35 × 10 -2 834 -0.026 (0.013) 4.04 × 10 -2
rs6589566 TG TE 2656 0.047 (0.007) 8.90 × 10 -11 1820 0.047 (0.009) 2.09 × 10 -7 836 0.049 (0.013) 1.22 × 10 -4
(A>G, APOA5)   NTE 2654 0.034 (0.007) 3.09 × 10 -6 1823 0.030 (0.009) 1.04 × 10 -3 831 0.042 (0.012) 6.99 × 10 -4
  HDLC TE 2656 -0.655 (0.350) 0.0615 1820 -0.698 (0.436) 0.110 836 -0.577 (0.589) 0.328
   NTE 2654 -1.519 (0.440) 5.55 × 10 -4 1823 -1.381 (0.539) 1.05 × 10 -2 831 -1.795 (0.762) 1.87 × 10 -2
rs4420638 LDLC TE 2659 6.028 (1.399) 1.63 × 10 -5 1821 5.713 (1.731) 9.86 × 10 -4 838 6.619 (2.373) 5.40 × 10 -4
(T>C, APOC1)   NTE 2654 2.789 (1.334) 0.0365 1820 3.027 (1.662) 0.0687 834 2.358 (2.236) 0.292
rs261332 HDLC TE 2658 1.026 (0.349) 3.29 × 10-3 1820 0.573 (0.436) 0.189 838 1.835 (0.583) 1.70 × 10-3
(G>A, LIPC)   NTE 2655 1.931 (0.434) 8.51 × 10-6 1821 2.204 (0.529) 3.21 × 10-5 834 1.369 (0.758) 0.0713
rs2156552 HDLC TE 2660 -1.102 (0.386) 4.28 × 10 -3 1823 -0.961 (0.477) 4.41 × 10 -2 837 -1.370 (0.656) 3.72 × 10 -2
(A>T, LIPG)   NTE 2657 -1.049 (0.478) 0.0283 1824 -1.383 (0.596) 2.03 × 10-2 833 -0.441 (0.804) 0.583
rs6586891 TG TE 2661 -0.015 (0.006) 0.0229 1824 -0.012 (0.008) 0.131 837 -0.021 (0.011) 0.0685
(C>A, LPL)   NTE 2656 -0.018 (0.006) 3.38 × 10-3 1824 -0.017 (0.008) 2.81 × 10-2 832 -0.020 (0.010) 0.0517
  HDLC TE 2661 0.897 (0.309) 3.71 × 10-3 1824 0.718 (0.379) 0.0584 837 1.251 (0.534) 1.93 × 10-2
   NTE 2656 1.404 (0.378) 2.00 × 10 -4 1824 1.046 (0.472) 2.68 × 10 -2 832 2.041 (0.629) 1.23 × 10 -3
  1. *Triglyceride (TG): log-transformed.
  2. Combined: combined meta-analysis of association signals in the KoGES and KCMS populations in a fixed effect model.
  3. Superscript p-values indicate significant associations. Significance: p < 0.005 (0.05/10 SNPs) in the combined population; p < 0.05 in the KoGES and KCMS populations.
  4. Boldface letters indicate reproducible associations in all three populations.