Effects of baicalin on renal function and histology 24 h after renal IRI. (A) Serum creatinine and blood urea nitrogen concentrations were significantly higher in the IR + saline than in the sham group. Pretreatment with 10 or 100 mg/kg baicalin dose-dependently inhibited renal dysfunction after renal IRI. (B) Baicalin amelioration of histological damage after IRI. (C) Baicalin reduction of MDA content and increase of SOD activity, indicating that baicalin reduced oxidative stress. *P < 0.05, **P < 0.01, ***P < 0.001.