PNS, Rg1, Rb1, and R1 treatment attenuated myocardial ischemic injuries in the complex mouse model. A. H&E staining was performed to examine the histological changes in the hearts. Myocardial necrotic degeneration, granulation and inflammatory cell infiltration were evident in the hearts from the vehicle-treated complex mice. PNS, Rg1, Rb1, or R1 treatment significantly attenuated these pathological features in the complex mice. Scale bars indicate 100 μm. B. Masson’s trichrome staining was performed and revealed significant myocardial fibrosis in the vehicle-treated complex mice, which was attenuated by PNS, Rg1, Rb1, and R1 treatment, respectively. Scale bars indicate 100 μm.