PNS or its major active components Rg1, Rb1, and R1 inhibited tumor growth in the complex mouse model. A. Growth curve of the tumor from vehicle-treated complex model (model), and PNS (150 mg/kg), Rg1 (50 mg/kg), Rb1 (50 mg/kg), R1 (10 mg/kg) treatment, respectively. Tumor volume (TV) (mm3) = (width2 × length)/2. B. Size of dissected tumor at the termination of experiment.