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Table 2 Cytotoxicity and antiviral activity of ellagic acid and antiviral agent ribavirin toward human rhinovirus-4 in HeLa cells using sulforhodamine B bioassay

From: Antiviral activity and possible mode of action of ellagic acid identified in Lagerstroemia speciosa leaves toward human rhinoviruses

Compound   HRV-2 HRV-3 HRV-4
  CC50(μg/mL) IC50(μg/mL) (±SD) TIa IC50(μg/mL) (±SD) TIa IC50(μg/mL) (±SD) TIa
Natural EAb >100 38 ± 3.2b >2.6 31 ± 5.2b >3.2 29 ± 2.5b >3.4
Pure EA >100 41 ± 1.1b >2.4 30 ± 2.4b >3.3 29 ± 1.7b >3.4
Ribavirin >100 70 ± 4.9a >1.4 71 ± 0.5a >1.4 63 ± 5.6a >1.6
  1. Means within a column followed by the same letter are not significantly different (P = 0.05, Bonferroni method).
  2. aTherapeutic index = CC50/IC50.
  3. bEllagic acid.