| |
Normal rats
|
STZ-diabetic rats
|
|---|
| |
Vehicle
|
Vehicle
|
PSLR 200
|
PSLR 300
|
|---|
|
Body weight (BW) (g/rat)
|
370.39 ± 13.58d
|
240.99 ± 16.24b
|
264.25 ± 15.11b,c
|
307.72 ± 14.72a,c
|
|
Kidney weight (KW) (g)
|
1.29 ± 0.23c
|
2.43 ± 0.17a
|
1.85 ± 0.24a
|
1.52 ± 0.16
|
|
KW/BW ratio × 1000
|
3.48 ± 0.19d
|
10.08 ± 0.17b
|
7.00 ± 0.12b,c
|
4.94 ± 0.11b,c
|
|
Plasma glucose (mg/dl)
|
92.68 ± 8.59d
|
425.73 ± 18.07b
|
336.25 ± 14.92b,c
|
306.92 ± 15.31b,c
|
|
HbAlc (%)
|
4.79 ± 1.03d
|
14.31 ± 1.26b
|
11.75 ± 1.18b
|
10.91 ± 1.21b
|
|
Urine volume (ml/day)
|
9.26 ± 2.43d
|
28.16 ± 9.13 b
|
18.21 ± 6.28b,c
|
15.84 ± 7.31b,c
|
|
Urine protein (mg/day)
|
6.95 ± 2.84d
|
34.83 ± 5.29b
|
16.41 ± 4.13a,c
|
12.27 ± 5.21d
|
|
Plasma Cr (μmol/l)
|
38.50 ± 6.34d
|
96.29 ± 8.73b
|
84.10 ± 8.31b
|
67.92 ± 7.32b,c
|
|
BUN (mmol/l)
|
7.21 ± 1.58c
|
16.29 ± 2.80a
|
13.16 ± 2.11a
|
11.45 ± 2.21a,c
|
|
Ccr (ml/min)
|
3.88 ± 0.89d
|
1.65 ± 0.54b
|
2.37 ± 0.68a,c
|
2.77 ± 0.34d
|
|
Plasma AST (U/l)
|
125.85 ± 10.47d
|
374.68 ± 17.34b
|
219.88 ± 18.26b,c
|
159.57 ± 17.53d
|
|
Plasma ALT (U/l)
|
57.67 ± 7.92d
|
218.67 ± 17.12b
|
145.14 ± 15.78b,c
|
103.42 ± 13.24a,d
|
|
Renal IL-6 (pg/mg protein)
|
54.06 ± 8.46d
|
159.34 ± 11.38b
|
126.34 ± 10.28b,c
|
105.89 ± 10.94b,c
|
|
Renal TNF-α (pg/mg protein)
|
69.19 ± 9.34d
|
172.91 ± 10.11b
|
137.12 ± 9.13b,c
|
109.45 ± 7.51b,c
|
|
Renal IL-10 (pg/mg protein)
|
64.77 ± 4.17d
|
28.43 ± 4.25b
|
36.49 ± 3.91b,c
|
44.64 ± 3.77b,c
|
- STZ-diabetic rats were dosed by oral gavage once per day for eight weeks with 200 mg/kg/day PSLR (PSLR 200), 300 mg/kg/day PSLR (PSLR 300). Normal or STZ-diabetic rats receiving vehicle treatment were given the same volume of vehicle (distilled water) used to disperse PSLR. Values (mean ± SD) were obtained for each group of 8 animals. aP < 0.05 and bP < 0.01 compared to the values of vehicle-treated normal rats, respectively. cP < 0.05 and dP < 0.01 compared to the values of vehicle-treated STZ-diabetic rats, respectively.
